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- W49207905 abstract "Bevacizumab (Avastin; Genentech, San Francisco, Calif.) is the first humanized monoclonal antibody targeting vascular endothelial growth factor receptor to be approved in combination with systemic chemotherapy for the treatment of advanced colorectal cancer.1 Despite its survival advantage for patients with metastatic colorectal cancer, this drug can delay healing of the wound and anastomosis.2Because the half-life of bevacizumab is 20 (11–50) days, which the drug monograph makes clear, bevacizumab should be stopped 28 days before a surgical procedure to minimize complications.2 Scappaticci and colleagues2 reported a 13% rate of wound complications in patients who underwent laparotomy less than 28 days after the last dose of bevacizumab, together with a rapidly decreasing risk of complications after that time.For many reasons, patients with metastatic colorectal cancer are more likely than others to require emergency surgical procedures.3 Because bevacizumab is used in a growing number of people with metastatic colorectal cancer, surgeons will have to operate increasingly frequently on this high-risk population.The purpose of this case report is to highlight the need for special precautions when a laparotomy is mandatory in patients treated with bevacizumab." @default.
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- W49207905 date "2008-06-01" @default.
- W49207905 modified "2023-10-04" @default.
- W49207905 title "Complications after colorectal anastomosis in a patient with metastatic rectal cancer treated with systemic chemotherapy and bevacizumab." @default.
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