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- W49252827 abstract "Peripheral blood mononuclear cells from thirty-one patients with inflammatory bowel disease (ulcerative colitis and Crohn's disease) were analysed for the proportions and absolute numbers of total T cells, and for the T cell subpopulations carrying Fc receptors for either IgM (Tmu cells) or IgG (T gamma cells). Twenty-six control subjects were studied simultaneously. Total T cell numbers were normal in patients with inflammatory bowel disease but there was a marked reduction in the proportion and absolute numbers of Tmu cells in patients, whether their disease was active or in remission. T gamma cells were normal. Simultaneous assessment of lymphocyte response to mitogens in vitro was performed in a group of patients. Responses to phytohaemagglutinin, concanavalin A and pokeweed mitogen were decreased and a positive correlation was found between the number of circulating Tmu cells and the responses to mitogens in vitro. These studies demonstrate that despite the presence of normal numbers of total T cells in inflammatory bowel disease, there is a marked imbalance in T cell subpopulations that correlates with mitogen responsiveness. This imbalance provides a possible cellular basis for the defect in cell-mediated immunity seen in these patients." @default.
- W49252827 created "2016-06-24" @default.
- W49252827 creator A5030438987 @default.
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- W49252827 date "1980-07-01" @default.
- W49252827 modified "2023-09-23" @default.
- W49252827 title "Alteration in T lymphocyte subpopulations in inflammatory bowel disease." @default.
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- W49252827 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1536922" @default.
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