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- W49286219 abstract "Dopamine is the dominant catecholamine neurotransmitter in the mammalian brain. It is found throughout the entire central nervous system, but is predominant in the nigrostriatal, mesolimbic, and tuberoinfundibular tracts (Creese et al., 1983). Dopamine exerts its effects through binding to two types of receptor, the D1 and D2 receptors (Kebabian and Calne, 1979). Binding of dopamine to its receptors induces several second messenger systems, most importantly affecting cAMP levels (Vallar and Meldolesi, 1989). Activation of the D1 receptor stimulates adenylyl cyclase activity which results in an increase in intracellular cAMP levels while binding of dopamine to the D2 receptor inhibits the cyclase activity (Caron et al., 1978)." @default.
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- W49286219 date "1992-01-01" @default.
- W49286219 modified "2023-09-26" @default.
- W49286219 title "The Dopamine D2 Receptor" @default.
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- W49286219 doi "https://doi.org/10.1007/978-1-4684-6772-7_7" @default.
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