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- W4930954 abstract "This chapter describes a few studies on a possible pathological significance of endorphins in psychiatric disorders. In the naloxone study, 40 schizophrenic patients were examined. The type of the study was a double-blind placebo-controlled cross-over design. Only patients with frequent hallucinations and/or actual delusional experience were included in the study. Psychopathological changes were registrated by use of the IMPS scale and by use of a self-constructed VBS-scale with 8 degrees of intensity, which can especially be adapted to hallucinations and actual delusional experience. The results showed a small but significant reduction of psychotic symptomatology when the average of the changes of 20 patients was evaluated. In the second part of the naloxone study, a naloxone dose of 24.8 mg was used to find out if a small antipsychotic effect can be increased with a higher dose." @default.
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- W4930954 date "1979-01-01" @default.
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- W4930954 title "Studies on a Possible Pathological Significance of Endorphins in Psychiatric Disorders" @default.
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- W4930954 doi "https://doi.org/10.1016/b978-0-08-023089-4.50060-0" @default.
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