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- W4931744 abstract "Alzheimer’s disease (AD) is characterized neuropathologically by the presence of two classical histologic hallmarks, neurofibrillary tangles (NFT) and senile plaques (SP). Recent analyses of the distribution of the pathologic changes in AD suggest that this disease affects select populations of neurons within the cerebral cortex that are characterized by specific regional and laminar distribution and connectivity patterns, whereas other neuronal subgroups are remarkably resistant to the degenerative process. Based on the distribution of NFT and SP, it has been proposed that a global corticocortical disconnection leads to the loss of integrated functions exhibited by AD patients. Furthermore, it appears that lesion distribution follows certain organization schemes and that these regional and laminar patterns may relate cortical circuits to clinical symptoms. Several neuropathologic studies have documented the presence of NFT and SP in the cerebral cortex of non-demented elderly individuals (Mountjoy et al., 1983; Tomlinson et al., 1968). More recently, it has been shown that amyloid deposition and NFT formation are not only common features of brain aging, but that they are present within certain regions of the cerebral cortex with densities comparable to those observed in demented patients (Bouras et al., 1993; Hof et al., 1992). Thus, high NFT densities have been demonstrated in the hippocampal formation and temporal neocortex, but sparse NFT in the other neocortical regions in cases presenting with very mild signs of cognitive decline (Bouras et al., 1993; Hof et al., 1992)." @default.
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- W4931744 date "1997-01-01" @default.
- W4931744 modified "2023-09-24" @default.
- W4931744 title "Regional Distribution of Neuropathological Changes in Alzheimer’s Disease" @default.
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- W4931744 doi "https://doi.org/10.1007/978-1-4612-4116-4_5" @default.
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