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- W49323 abstract "Many pathogenic mycoplasmas are parasites of the respiratory and urogenital tracts. They can be considered to be surface parasites, as they do not useally invade the tissues and blood stream. The adherence of the mycoplasmas to the epithelial cell surface is apparently the first stage in the disease process. The interaction occurs between binding sites of a proteinous nature on the mycoplasma cell membrane and receptors on the host cell membrane. There is strong evidence available indicating that sialic acid residues on host cells play an important role in the adherence of M. gallisepticum and M. pneumoniae. However, other host cell membrane components may also participate in the interaction. While several studies indicate that M. gallisepticum and M. pneumoniae adhere to the host cell with their blebs or terminal structures, others suggest that binding can occur via other areas of the cell. Our scanning electron microscopy studies suggest a very tight interaction between these mycoplasmas and the red blood cell (RBC) membrane, causing imprints resembling those observed upon interaction of viruses with RBC. Our approach for isolating the binding sites of M. pneumoniae to RBC was based on the finding that sialoglycoproteins are major receptor sites for attachment of these organisms to respiratory epithelium and to RBC. Glycophorin, the major sialoglycoprotein of human RBC, was used as a ligand in affinity chromatography for the isolation of the binding sites specific for sialic acid receptors from M. pneumoniae membranes solubilized by detergents. The fraction which was eluted with 0.2% SDS from the glycophorin- Sepharose column was highly enriched with two proteins (with an apparent molecular weight of 45,000 and 25,000). It exhibited high binding capacity to glycophorin- Sepharose beads, and a lower binding capacity to human RBC. The binding of this fraction to RBC was almost completely abolished by glycophorin, but not by its hydrophobic moiety. These studies may pave the way for further characterization of the binding sites." @default.
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- W49323 date "1981-01-01" @default.
- W49323 modified "2023-09-26" @default.
- W49323 title "Adherence of Mycoplasmas to Host Cell Membranes" @default.
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- W49323 doi "https://doi.org/10.1016/b978-0-08-026381-6.50013-9" @default.
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