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- W49369910 abstract "Extracorporeal circulation used in cardiopulmonary bypass and hemodialysis is often associated with severe hypotension which is an important predictor for mortality and morbidity. One pathophysiological hypothesis includes nitric oxide (NO) generation. Recently, a functional NO-synthase (endothelial type NO-synthase; eNOS), was found to be expressed in human red blood cells (RBC). However, to date, activation of RBC eNOS has not been shown. We hypothesised that eNOS in circulating RBC might be activated during extracorporeal circulation and thus contribute to hypotension through vasodilation upon NO release. We collected blood samples from twenty-eight patients electively subjected to cardiac surgery during cardiopulmonary bypass (CPB) (0 min, 20 min, 40 min, 60 min and 80 min of CPB). RBCs were immunohistochemically stained against activated eNOS. The degree of activation was assessed by TV-densitometry (gray units). We found significant RBC eNOS activation during cardiopulmonary bypass in a time dependent fashion (from 2.1±0.4 gray units at 0 min to 2.9±0.2, 3.7±0.4, 4.4±3.4, and 4.8±0.4 gray units at 20, 40, 60, and 80 min of CPB, respectively. eNOS activation occurred by dissociation of the enzyme from the cellular membrane into the cytosol (translocation). The correlation between activated eNOS and CPB duration was highly significant (r = 0.98; p = 0.0008). RBC might contribute to hypotension through vasodilation upon NO release during extracorporeal circulation." @default.
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- W49369910 date "2007-01-01" @default.
- W49369910 modified "2023-10-14" @default.
- W49369910 title "Extracorporeal Circulation activates endothelial Nitric Oxide Synthase (eNOS) in Erythrocytes" @default.
- W49369910 doi "https://doi.org/10.1096/fasebj.21.6.a1230" @default.
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