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- W49406975 abstract "Alzheimer's Disease (AD) is characterized by progressive neurodegeneration which is thought to result, in part, from the deposition of amyloid-beta (Aβ) protein in the brain. Even though the levels of Aβ in the brain of Alzheimer's patients are presumably very high, the levels in the plasma are difficult to assess. Currently, secretase-inhibitors and immunotherapy are under development as potential therapeutic strategies for AD. Therefore, a safe, accurate, and sensitive diagnostic test for pre-clinical AD is of critical importance. It has been previously shown that injection of antibodies directed against Aβ into a transgenic mouse model of AD result in an efflux of soluble Aβ from the brain to the blood, and that levels of Aβ in the blood positively correlate with the amount of Aβ deposited in the brain (DeMatttos, 2002). The objective of this study is to maximize the detection of soluble Aβ species in plasma of transgenic mice, prior to and after the deposition of Aβ in the brain. To that effect, we use a biotinylated Aβ antibody (B-IB3) in a novel conditional mouse model of AD (CamKII-ttA x tetAPP/swe/ind) (Jankowsky 2006) to induce a measurable efflux of Aβ from the brain to the plasma. We have found that the levels of plasma Aβ were highest in young mice that had not yet begun depositing Aβ in the brain. Therefore, we believe that this method has potential as a test for pre-clinical AD." @default.
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- W49406975 date "2007-04-01" @default.
- W49406975 modified "2023-10-17" @default.
- W49406975 title "Biotinylated anti‐Aβ antibody as a tool to diagnose pre‐clinical stages of Alzheimer's Disease (AD)" @default.
- W49406975 doi "https://doi.org/10.1096/fasebj.21.5.a20-a" @default.
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