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- W49470665 abstract "Immunodominant Major Histocompatibility Complex class I (MHC I)- associated epitopes suppress T-cell responses against cryptic epitopes. That is, when confronted with complex antigens, CD8+ T cells respond to only a few “immunodominant” epitopes and neglect other “cryptic” peptides that would otherwise be immunogenic when presented alone. Immunodominant epitopes are better immunogens than cryptic epitopes. Compared with T cells specific for cryptic epitopes, CD8+ T cells that recognize immunodominant epitopes interact with their antigen with higher avidity, are primed after a shorter duration of antigen presentation, expand more swiftly and extensively, and generate more potent effector function. Furthermore, by curtailing the duration of Ag presentation [through deletion or exhaustion of antigen presenting cells (APCs)], immunodominant CD8+ effector T cells selectively impair priming against cryptic epitopes. Immunodominance results in one major advantage and one potential drawback: that is, immunodominance favors expansion of the fittest effector T cells but may enhance the risk of immune escape by antigen-loss variants. Targeting immunodominant epitopes is probably crucial not only for success of immune responses against pathogens but also in cancer immunotherapy. Indeed, CD8+ T cells targeted to immunodominant but not cryptic minor histocompatibility antigens can eradicate leukemia and melanoma in mice. In this chapter, I will review the current state-of-the-art regarding T-cell immunodominance and discuss key elements of ongoing and future research in this area." @default.
- W49470665 created "2016-06-24" @default.
- W49470665 creator A5053448893 @default.
- W49470665 date "2010-11-12" @default.
- W49470665 modified "2023-10-09" @default.
- W49470665 title "Mechanisms and Implications of Immunodominance in CD8+ T-Cell Responses" @default.
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- W49470665 doi "https://doi.org/10.1007/978-1-60761-980-2_9" @default.
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