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- W4947319 abstract "Metabolic endotoxemia can initiate obesity and insulin resistance. Prebiotic fiber can reduce metabolic endotoxemia and intestinal permeability as measured by plasma lipopolysaccharide (LPS). Offspring of rats fed a low protein diet during pregnancy are at high risk of obesity which may be related to increased intestinal permeability. Our objective was to determine if prebiotic fiber minimized this effect. Virgin Wistar dams received AIN-93G (normal protein, NP) or a low protein (LP) diet (7% wt/wt) during pregnancy. Female offspring were weaned onto control or a high prebiotic fiber diet (21% wt/wt 1:1 oligofructose and inulin) (HF). Body composition was analyzed along with plasma LPS concentrations at 24 wk of age. Gene expression in the colon was analyzed for tight junction protein-1 (TJP-1). There was no difference in overall body weight but lean mass was greater in offspring consuming HF (P=0.013). HF was associated with higher plasma LPS in LP-exposed versus NP-exposed offspring (P=0.009). TJP1 mRNA levels were higher in NP-exposed offspring whether consuming C or HF (P=0.05). A maternal diet low in protein is associated with a ‘leaky gut’ in female offspring which has the potential for negative metabolic effects. Contrary to adult obesity, HF was not able to correct metabolic endotoxemia in female offspring of LP dams." @default.
- W4947319 created "2016-06-24" @default.
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- W4947319 date "2013-04-01" @default.
- W4947319 modified "2023-09-27" @default.
- W4947319 title "Prebiotic fiber diet does not improve offspring ‘leaky gut’ from maternal low protein diet" @default.
- W4947319 doi "https://doi.org/10.1096/fasebj.27.1_supplement.1058.2" @default.
- W4947319 hasPublicationYear "2013" @default.
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