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• W49520081 abstract "Glucagon is a flexible hormone which has little secondary structure in aqueous solutions at high dilution, but which assumes a helical conformation in more concentrated solutions. The helix is stabilised by the formation of trimers and higher oligomers, the structure of which has been studied in detail by X-ray analysis. It is proposed that glucagon exists as trimers in A-cell granules, that it forms an equilibrium population of conformers in the monomeric state during circulation and that a helical conformer is induced at and bound by the receptor. X-ray diffraction and circular dichroism experiments show that the avian pancreatic hormone III also has a highly helical structure but is more compact and associates as dimers in crystals." @default.
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• W49520081 date "1978-01-01" @default.
• W49520081 modified "2023-10-17" @default.
• W49520081 title "GLUCAGON AND PANCREATIC HORMONE III: X-RAY ANALYSIS, CONFORMATION AND RECEPTOR BINDING" @default.
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• W49520081 doi "https://doi.org/10.1016/b978-0-08-022626-2.50032-8" @default.
• W49520081 hasPublicationYear "1978" @default.
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