FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W49589729> ?p ?o ?g. }

• W49589729 endingPage "205" @default.
• W49589729 startingPage "181" @default.
• W49589729 abstract "ATP-binding cassette (ABC) transporters mediate active transport of a variety of substrates across biological membranes. The long studied maltose importer from Escherichia coli has provided a wealth of biochemical and genetic information, making it an attractive target for structure determination. The maltose transporter is a complex composed of a heterodimer of transmembrane subunits and a nucleotide-binding subunit homodimer that together function in concert with a periplasmic-binding protein, responsible for delivery of maltose to the transporter. The complex has now been crystallized in multiple states along the translocation pathway. Functional studies were key for stabilizing the transporter in these conformational states, validating the structures and understanding the molecular mechanism of transport. ATP hydrolysis and substrate transport are coupled via concerted conformational changes spanning the bilayer that result in alternating access of the substrate-binding site to either side of the membrane. Although the detailed dynamics of the complex remain to be revealed, we illustrate here how the interplay between biochemical, biophysical, and structural studies established the maltose transporter as one of the best characterized proteins of the ABC family. While many of these molecular insights are relevant to the entire ABC transporter family, some mechanistic features may differ between subclasses, highlighting the extraordinary diversity of ABC proteins and the need for further structure/function analyses." @default.
• W49589729 created "2016-06-24" @default.
• W49589729 creator A5012201570 @default.
• W49589729 creator A5064666218 @default.
• W49589729 creator A5078325329 @default.
• W49589729 date "2014-01-01" @default.
• W49589729 modified "2023-10-09" @default.
• W49589729 title "The Maltose ABC Transporter: Where Structure Meets Function" @default.
• W49589729 cites W1486598550 @default.
• W49589729 cites W1488743900 @default.
• W49589729 cites W1490002405 @default.
• W49589729 cites W1497732644 @default.
• W49589729 cites W1511766554 @default.
• W49589729 cites W1529506325 @default.
• W49589729 cites W1549300234 @default.
• W49589729 cites W1568913568 @default.
• W49589729 cites W1579211638 @default.
• W49589729 cites W1581832566 @default.
• W49589729 cites W1585164939 @default.
• W49589729 cites W1590926802 @default.
• W49589729 cites W1630052702 @default.
• W49589729 cites W1658694464 @default.
• W49589729 cites W1693529071 @default.
• W49589729 cites W1708448089 @default.
• W49589729 cites W1714769843 @default.
• W49589729 cites W1938292149 @default.
• W49589729 cites W1938522541 @default.
• W49589729 cites W1966791265 @default.
• W49589729 cites W1967105053 @default.
• W49589729 cites W1968204553 @default.
• W49589729 cites W1969008019 @default.
• W49589729 cites W1972053619 @default.
• W49589729 cites W1972491811 @default.
• W49589729 cites W1973876121 @default.
• W49589729 cites W1974652764 @default.
• W49589729 cites W1978482772 @default.
• W49589729 cites W1978530172 @default.
• W49589729 cites W1979887720 @default.
• W49589729 cites W1980147119 @default.
• W49589729 cites W1980179932 @default.
• W49589729 cites W1980897131 @default.
• W49589729 cites W1981893537 @default.
• W49589729 cites W1982917248 @default.
• W49589729 cites W1984048380 @default.
• W49589729 cites W1984717522 @default.
• W49589729 cites W1987641460 @default.
• W49589729 cites W1993930618 @default.
• W49589729 cites W1994772523 @default.
• W49589729 cites W1995859158 @default.
• W49589729 cites W1996272077 @default.
• W49589729 cites W1997394341 @default.
• W49589729 cites W1997432723 @default.
• W49589729 cites W1998428612 @default.
• W49589729 cites W1998665732 @default.
• W49589729 cites W2002446300 @default.
• W49589729 cites W2002836562 @default.
• W49589729 cites W2006373328 @default.
• W49589729 cites W2008239057 @default.
• W49589729 cites W2010508088 @default.
• W49589729 cites W2016848332 @default.
• W49589729 cites W2022132556 @default.
• W49589729 cites W2022716663 @default.
• W49589729 cites W2026984793 @default.
• W49589729 cites W2027394451 @default.
• W49589729 cites W2029726401 @default.
• W49589729 cites W2033526989 @default.
• W49589729 cites W2035506170 @default.
• W49589729 cites W2036842869 @default.
• W49589729 cites W2037228365 @default.
• W49589729 cites W2037882698 @default.
• W49589729 cites W2039771729 @default.
• W49589729 cites W2040898023 @default.
• W49589729 cites W2042174783 @default.
• W49589729 cites W2046167970 @default.
• W49589729 cites W2048682708 @default.
• W49589729 cites W2049478377 @default.
• W49589729 cites W2052146488 @default.
• W49589729 cites W2056082671 @default.
• W49589729 cites W2057788409 @default.
• W49589729 cites W2058689517 @default.
• W49589729 cites W2059986155 @default.
• W49589729 cites W2060772173 @default.
• W49589729 cites W2062487592 @default.
• W49589729 cites W2063047484 @default.
• W49589729 cites W2063623087 @default.
• W49589729 cites W2065497078 @default.
• W49589729 cites W2068182196 @default.
• W49589729 cites W2072135452 @default.
• W49589729 cites W2077555752 @default.
• W49589729 cites W2084268572 @default.
• W49589729 cites W2086013110 @default.
• W49589729 cites W2087938597 @default.
• W49589729 cites W2091099572 @default.
• W49589729 cites W2091821514 @default.
• W49589729 cites W2092435069 @default.
• W49589729 cites W2095182463 @default.
• W49589729 cites W2095374620 @default.
• W49589729 cites W2097561703 @default.

• next