Matches in SemOpenAlex for { <https://semopenalex.org/work/W49594940> ?p ?o ?g. }
- W49594940 abstract "ABSTRACT Macrophages are central in orchestrating the innate immune response to infection, representing both the janitor and the security guard. While performing their normal scavenging functions in various tissues they will, at the same time, survey the tissues for pathogenic intruders. This is not a trivial task: They must be able to discriminate microbes from self, and then initiate a proper response. The discovery of the Toll-like receptor (TLR) family of pattern-recognition receptors has provided a better understanding of how this can be done. TLRs are expressed on macrophages and other innate immune cells, where they collaborate to read the molecular fingerprint of different microbes and initiate inflammatory signalling pathways. It is becoming clear that the TLR family is important in infectious diseases, and there is also evidence that they may play a role in autoimmunity and degenerative diseases in the central nervous system. In this review we will give an overview of the current knowledge of pathogen recognition by TLRs." @default.
- W49594940 created "2016-06-24" @default.
- W49594940 creator A5011458022 @default.
- W49594940 creator A5063227404 @default.
- W49594940 date "2005-01-01" @default.
- W49594940 modified "2023-09-25" @default.
- W49594940 title "Pathogen Recognition by Toll-like Receptors" @default.
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- W49594940 doi "https://doi.org/10.1016/s1567-7443(05)80015-8" @default.
- W49594940 hasPublicationYear "2005" @default.
- W49594940 type Work @default.
- W49594940 sameAs 49594940 @default.