Matches in SemOpenAlex for { <https://semopenalex.org/work/W49662988> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W49662988 endingPage "49.15" @default.
- W49662988 startingPage "49.15" @default.
- W49662988 abstract "Abstract The function of the Sle2 mouse lupus susceptibility locus and its derived Sle2c1sublocus have been previously shown to be associated with a lower threshold of activation of the BCR leading to an accumulation of B1a cells in NZM2410 model. To explore whether these loci had any effects on other immune components, we introduced lpr as an amplifier into B6.Sle2 and its subcongenic strains, and analyzed systemically their cellular and functional phenotypes. Consequently it was found that the co-expression of Sle2 and lpr on a C57BL/6 background significantly increased lymphadenopathy primarily targeting T cells, as well as induced renal pathology which included heavy lymphoid infiltrates. Comparison of the 3 Sle2 subloci mapped the synergistic interaction with lpr to Sle2c. Further examination of both Fas-deficient and Fas-intact mice showed that Sle2c1 resulted in increased T cell proliferation, a reduced IL-2 production, and a reduced Foxp3+ regulatory T cell compartment in spleen and lymph nodes, phenotypes which are characteristic of lupus in human patients and mouse models. Our results demonstrate that the Sle2c1 locus contains a candidate gene which, in addition to regulate BRC activation threshold, also affects T cells homeostasis through altering IL-2 production and Treg cell balance." @default.
- W49662988 created "2016-06-24" @default.
- W49662988 creator A5002019326 @default.
- W49662988 creator A5026532447 @default.
- W49662988 date "2009-04-01" @default.
- W49662988 modified "2023-09-25" @default.
- W49662988 title "The Sle2c1 murine susceptibility locus controls T cell homeostasis through defective IL-2 production (49.15)" @default.
- W49662988 doi "https://doi.org/10.4049/jimmunol.182.supp.49.15" @default.
- W49662988 hasPublicationYear "2009" @default.
- W49662988 type Work @default.
- W49662988 sameAs 49662988 @default.
- W49662988 citedByCount "0" @default.
- W49662988 crossrefType "journal-article" @default.
- W49662988 hasAuthorship W49662988A5002019326 @default.
- W49662988 hasAuthorship W49662988A5026532447 @default.
- W49662988 hasConcept C104317684 @default.
- W49662988 hasConcept C127716648 @default.
- W49662988 hasConcept C153911025 @default.
- W49662988 hasConcept C203014093 @default.
- W49662988 hasConcept C2776090121 @default.
- W49662988 hasConcept C2779727006 @default.
- W49662988 hasConcept C2780931953 @default.
- W49662988 hasConcept C54355233 @default.
- W49662988 hasConcept C63645605 @default.
- W49662988 hasConcept C84597430 @default.
- W49662988 hasConcept C86803240 @default.
- W49662988 hasConcept C8891405 @default.
- W49662988 hasConcept C95444343 @default.
- W49662988 hasConceptScore W49662988C104317684 @default.
- W49662988 hasConceptScore W49662988C127716648 @default.
- W49662988 hasConceptScore W49662988C153911025 @default.
- W49662988 hasConceptScore W49662988C203014093 @default.
- W49662988 hasConceptScore W49662988C2776090121 @default.
- W49662988 hasConceptScore W49662988C2779727006 @default.
- W49662988 hasConceptScore W49662988C2780931953 @default.
- W49662988 hasConceptScore W49662988C54355233 @default.
- W49662988 hasConceptScore W49662988C63645605 @default.
- W49662988 hasConceptScore W49662988C84597430 @default.
- W49662988 hasConceptScore W49662988C86803240 @default.
- W49662988 hasConceptScore W49662988C8891405 @default.
- W49662988 hasConceptScore W49662988C95444343 @default.
- W49662988 hasIssue "1_Supplement" @default.
- W49662988 hasLocation W496629881 @default.
- W49662988 hasOpenAccess W49662988 @default.
- W49662988 hasPrimaryLocation W496629881 @default.
- W49662988 hasRelatedWork W1967782952 @default.
- W49662988 hasRelatedWork W2002737652 @default.
- W49662988 hasRelatedWork W2036107469 @default.
- W49662988 hasRelatedWork W2081358646 @default.
- W49662988 hasRelatedWork W2153797564 @default.
- W49662988 hasRelatedWork W2382901196 @default.
- W49662988 hasRelatedWork W3036195848 @default.
- W49662988 hasRelatedWork W3201639896 @default.
- W49662988 hasRelatedWork W4365803899 @default.
- W49662988 hasRelatedWork W2781693618 @default.
- W49662988 hasVolume "182" @default.
- W49662988 isParatext "false" @default.
- W49662988 isRetracted "false" @default.
- W49662988 magId "49662988" @default.
- W49662988 workType "article" @default.