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- W49697156 abstract "Alzheimer’s disease is heterogeneous: more than a single genetic mutation accounts for several of the early onset AD recognizable phenotypes, and more than one genetic locus is linked to late onset and early onset phenotypes. Heterogeneity means different things to many investigators so it is important to define clearly the terms of reference. Locus heterogeneity may mean that AD is several totally independent processes that eventually develop into the clinical and pathologic picture defined as AD. However, it may also refer to several different loci involved in a common pathogenesis. In that case it may be possible to piece together the puzzle of disease pathogenesis by defining the relevant gene loci that contribute to the phenotype (Table 1).KeywordsDuchenne Muscular DystrophyAmyloid Precursor ProteinAmyloid Precursor Protein GeneDuchenne Muscular Dystrophy GeneHereditary Cerebral HemorrhageThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves." @default.
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- W49697156 date "1992-01-01" @default.
- W49697156 modified "2023-09-27" @default.
- W49697156 title "Locus Heterogeneity of Alzheimer’s Disease" @default.
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- W49697156 doi "https://doi.org/10.1007/978-3-642-46776-9_12" @default.
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