Matches in SemOpenAlex for { <https://semopenalex.org/work/W49780242> ?p ?o ?g. }
- W49780242 endingPage "440" @default.
- W49780242 startingPage "379" @default.
- W49780242 abstract "This chapter critically reviews our current understanding of the pathogenesis, clinical syndrome, and therapy of the disturbances of renal sodium handling, renal perfusion, and glomerular filtration rate that occur in patients with Laennec's cirrhosis. Avid renal sodium reabsorption, a characteristic feature of cirrhosis, occurs independent of moderate changes in renal function and precedes the onset of ascites. The initiation of sodium retention may be a direct consequence of the hepatic disease process and may also result from defective intravascular filling. In the presence of ascites the most important sodium retaining signal is a defective intravascular volume. The principal effectors of renal sodium retention and vasoconstriction are stimulation of the renin-angiotensin-aldosterone axis and augmentation of renal sympathetic nerve activity. Deficient production of natriuretic hormone(s) and endogenous renal vasodilators, such as prostaglandins and kinins, also contributes to the sodium retention and renal hypoperfusion seen in cirrhosis. The hepatorenal syndrome is an extreme imbalance in these renal vasoconstrictor and vasodilator forces. In the therapy of ascites in Laennec's cirrhosis, abstention from alcohol, sodium restriction, and cautious diuresis are the principal therapeutic measures. A grave prognosis accompanies the diagnosis of the hepatorenal syndrome although recoveries have been reported." @default.
- W49780242 created "2016-06-24" @default.
- W49780242 creator A5032714638 @default.
- W49780242 creator A5083218494 @default.
- W49780242 date "1986-01-01" @default.
- W49780242 modified "2023-09-27" @default.
- W49780242 title "The Pathogenesis of Renal Sodium Retention and Ascites Formation in Laennec’s Cirrhosis" @default.
- W49780242 cites W1483437251 @default.
- W49780242 cites W1503874547 @default.
- W49780242 cites W1518247835 @default.
- W49780242 cites W1564556829 @default.
- W49780242 cites W1567509578 @default.
- W49780242 cites W1615580594 @default.
- W49780242 cites W1623673702 @default.
- W49780242 cites W1706076699 @default.
- W49780242 cites W1775764897 @default.
- W49780242 cites W1821554906 @default.
- W49780242 cites W1846241591 @default.
- W49780242 cites W1857552597 @default.
- W49780242 cites W1873458064 @default.
- W49780242 cites W1916614783 @default.
- W49780242 cites W1953464220 @default.
- W49780242 cites W1972477785 @default.
- W49780242 cites W1972965645 @default.
- W49780242 cites W1974929635 @default.
- W49780242 cites W1975285976 @default.
- W49780242 cites W1978686080 @default.
- W49780242 cites W1979651804 @default.
- W49780242 cites W1980839726 @default.
- W49780242 cites W1984985613 @default.
- W49780242 cites W1987976961 @default.
- W49780242 cites W1987981002 @default.
- W49780242 cites W1988338186 @default.
- W49780242 cites W1988804182 @default.
- W49780242 cites W1991653058 @default.
- W49780242 cites W1991751952 @default.
- W49780242 cites W1992463921 @default.
- W49780242 cites W1993308904 @default.
- W49780242 cites W1993641488 @default.
- W49780242 cites W1993708319 @default.
- W49780242 cites W1994157271 @default.
- W49780242 cites W1995203853 @default.
- W49780242 cites W1996717405 @default.
- W49780242 cites W1997363755 @default.
- W49780242 cites W1998687765 @default.
- W49780242 cites W1999322668 @default.
- W49780242 cites W2001974766 @default.
- W49780242 cites W2004175731 @default.
- W49780242 cites W2005403960 @default.
- W49780242 cites W2006677117 @default.
- W49780242 cites W2007221087 @default.
- W49780242 cites W2007413141 @default.
- W49780242 cites W2008434938 @default.
- W49780242 cites W2010788509 @default.
- W49780242 cites W2011699421 @default.
- W49780242 cites W2011842952 @default.
- W49780242 cites W2012894694 @default.
- W49780242 cites W2013097012 @default.
- W49780242 cites W2016350815 @default.
- W49780242 cites W2016969540 @default.
- W49780242 cites W2017940925 @default.
- W49780242 cites W2019118066 @default.
- W49780242 cites W2019673763 @default.
- W49780242 cites W2020364371 @default.
- W49780242 cites W2021039380 @default.
- W49780242 cites W2021104395 @default.
- W49780242 cites W2022128836 @default.
- W49780242 cites W2022375793 @default.
- W49780242 cites W2022412570 @default.
- W49780242 cites W2023081527 @default.
- W49780242 cites W2024211838 @default.
- W49780242 cites W2027227750 @default.
- W49780242 cites W2029414689 @default.
- W49780242 cites W2031189373 @default.
- W49780242 cites W2032350393 @default.
- W49780242 cites W2033098139 @default.
- W49780242 cites W2033681619 @default.
- W49780242 cites W2033710804 @default.
- W49780242 cites W2034376730 @default.
- W49780242 cites W2034955733 @default.
- W49780242 cites W2036206860 @default.
- W49780242 cites W2036487592 @default.
- W49780242 cites W2039681877 @default.
- W49780242 cites W2042972296 @default.
- W49780242 cites W2043633112 @default.
- W49780242 cites W2044158648 @default.
- W49780242 cites W2044343880 @default.
- W49780242 cites W2045979716 @default.
- W49780242 cites W2049910843 @default.
- W49780242 cites W2056069181 @default.
- W49780242 cites W2056708771 @default.
- W49780242 cites W2060338318 @default.
- W49780242 cites W2060350295 @default.
- W49780242 cites W2062435953 @default.
- W49780242 cites W2062824004 @default.
- W49780242 cites W2063528071 @default.
- W49780242 cites W2064142851 @default.
- W49780242 cites W2064786608 @default.