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- W49857897 abstract "Obtaining a quantitative description of metabolic regulation is essential in understanding metabolic systems under perturbed conditions such as ischemic myocardial tissues. The authors have implemented a mathematical model of glycolysis in human erythrocytes described by Holzhuetter et. al. in order to study the change of regulation pattern during perturbed conditions. Holzhuetter's model as well as a similar model described by A. Werner and R. Heinrich, which takes into account the osmotic state of erythrocytes, predict that the flux of glycolytic pathway increases as the rate of ATP-consuming process increases. The authors have measured the glycolytic flux using /sup 13/C NMR with valinomycin as a perturbant to increase the Na/sup +//K/sup +/ ATPase activity. Upon the addition of valinomycin, increased glycolytic flux and decreased steady state concentration of ATP was observed. Currently, the authors are implementing a more advanced model based on Werner and Heinrich to simulate the effect of valinomycin and study the possible change of distribution of control points along the metabolic pathway." @default.
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- W49857897 date "1986-05-01" @default.
- W49857897 modified "2023-09-23" @default.
- W49857897 title "Control analysis of red cell glycolysis: combined NMR and computer modeling studies" @default.
- W49857897 hasPublicationYear "1986" @default.
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