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- W50012918 abstract "目的：探讨鼻咽癌细胞中PK3K/AKT和ERK/MAPK信号传导通路异常激活与鼻咽癌细胞发生发展的关系。方法：蛋白质印迹法检测3例鼻咽低分化鳞癌组织及其细胞株（CNE2）和鼻咽炎性组织中IGF-1R、AKT和ERK1/2蛋白的表达情况;相同实验方法检测鼻咽癌细胞株CNE2中磷酸化的PAKT和pERK1/2蛋白的表达和给予胰岛素样生长因子-1（IGF-1）刺激癌细胞后磷酸化的pAKT和pERK的表达水平,再分别用PKB/AKT和ERK/MAPK通路抑制剂对CNE2细胞信号传导通路磷酸化的调节作用进行抑制试验。结果：3例鼻咽低分化鳞癌组织和CNE2细胞株中IGF-1R、AKT和ERK1/2蛋白表达水平明显高于鼻咽炎性组织;IGF-1可刺激CNE2细胞中pAKT和pERK1/2的表达增加,与空白对照组相比,其pAKT和pERK表达量明显增高;给予Wort-mannin和PD98059治疗24和48h后,CNE2细胞株生长明显受到抑制。结论：IGF-1R的过度表达及其PK3K/AKT、ERK/MAPK信号传导通路的异常激活在鼻咽癌的发生、发展过程中可能起着非常重要的作用,IGF-1R系统有可能作为复发或转移性鼻咽癌治疗中一个潜在的靶分子。" @default.
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- W50012918 date "2009-01-01" @default.
- W50012918 modified "2023-09-24" @default.
- W50012918 title "鼻咽癌细胞PI3K/AKT和ERK/MAPK信号通路活性表达及其临床意义的探讨" @default.
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