Matches in SemOpenAlex for { <https://semopenalex.org/work/W50021174> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W50021174 abstract "SK and F 101926 is a synthetic analogue of vasopressin which antagonizes vasopressin induced antidiuresis. Radiolabeled SK and F 101926 (/sup 3/H-3,3-D-TYR) was administered i.v. as a single bolus to male Sprague Dawley rats. Serial plasma samples were analyzed for SK and F 101926 by HPLC/LSC. The plasma concentration time curve for SK and F 101926 displayed three disposition phases. However, 80% of the total area under the curve was represented in one phase which displayed a half-life (t 1/2) of 20 min. The total systematic clearance (Cl) and the steady state volume of distribution (Vdss) were 15 ml/min/kg and 450 ml/kg, respectively. The t 1/2, Cl and Vdss were identical following doses of 10 and 100 ..mu..g/kg. /sup 3/H-SK and F 101926 accounted for > 80% of the plasma radiolabel 0-30 min after dosing. However, by 12 hr, /sup 3/H-SK and F 101926 represented only 6% of the plasma radiolabel. Following oral administration of /sup 3/H-SK and F 101926, < 5% of the administered radiolabel reached the systematic circulation; however, no parent compound was detectable in plasma. These studies demonstrate that although SK and F 101926 has a relatively low systematic clearance, it also displays a relatively small volumemore » of distribution which together result in a moderate beta elimination half-life.« less" @default.
- W50021174 created "2016-06-24" @default.
- W50021174 creator A5007609628 @default.
- W50021174 creator A5015904916 @default.
- W50021174 creator A5042330297 @default.
- W50021174 creator A5090309105 @default.
- W50021174 date "1986-03-01" @default.
- W50021174 modified "2023-09-23" @default.
- W50021174 title "Pharmacokinetics of the vasopressin antagonist, SK and F 101926, a synthetic octapeptide, in the rat" @default.
- W50021174 hasPublicationYear "1986" @default.
- W50021174 type Work @default.
- W50021174 sameAs 50021174 @default.
- W50021174 citedByCount "0" @default.
- W50021174 crossrefType "journal-article" @default.
- W50021174 hasAuthorship W50021174A5007609628 @default.
- W50021174 hasAuthorship W50021174A5015904916 @default.
- W50021174 hasAuthorship W50021174A5042330297 @default.
- W50021174 hasAuthorship W50021174A5090309105 @default.
- W50021174 hasConcept C110121322 @default.
- W50021174 hasConcept C112705442 @default.
- W50021174 hasConcept C126322002 @default.
- W50021174 hasConcept C134018914 @default.
- W50021174 hasConcept C134306372 @default.
- W50021174 hasConcept C139254425 @default.
- W50021174 hasConcept C170493617 @default.
- W50021174 hasConcept C185592680 @default.
- W50021174 hasConcept C2776370428 @default.
- W50021174 hasConcept C2776885963 @default.
- W50021174 hasConcept C3020190219 @default.
- W50021174 hasConcept C33923547 @default.
- W50021174 hasConcept C3941253 @default.
- W50021174 hasConcept C43376680 @default.
- W50021174 hasConcept C55493867 @default.
- W50021174 hasConcept C71924100 @default.
- W50021174 hasConceptScore W50021174C110121322 @default.
- W50021174 hasConceptScore W50021174C112705442 @default.
- W50021174 hasConceptScore W50021174C126322002 @default.
- W50021174 hasConceptScore W50021174C134018914 @default.
- W50021174 hasConceptScore W50021174C134306372 @default.
- W50021174 hasConceptScore W50021174C139254425 @default.
- W50021174 hasConceptScore W50021174C170493617 @default.
- W50021174 hasConceptScore W50021174C185592680 @default.
- W50021174 hasConceptScore W50021174C2776370428 @default.
- W50021174 hasConceptScore W50021174C2776885963 @default.
- W50021174 hasConceptScore W50021174C3020190219 @default.
- W50021174 hasConceptScore W50021174C33923547 @default.
- W50021174 hasConceptScore W50021174C3941253 @default.
- W50021174 hasConceptScore W50021174C43376680 @default.
- W50021174 hasConceptScore W50021174C55493867 @default.
- W50021174 hasConceptScore W50021174C71924100 @default.
- W50021174 hasLocation W500211741 @default.
- W50021174 hasOpenAccess W50021174 @default.
- W50021174 hasPrimaryLocation W500211741 @default.
- W50021174 hasRelatedWork W1536899719 @default.
- W50021174 hasRelatedWork W1972545455 @default.
- W50021174 hasRelatedWork W1993072922 @default.
- W50021174 hasRelatedWork W2028169006 @default.
- W50021174 hasRelatedWork W2065250585 @default.
- W50021174 hasRelatedWork W2079227113 @default.
- W50021174 hasRelatedWork W2106548079 @default.
- W50021174 hasRelatedWork W2138489899 @default.
- W50021174 hasRelatedWork W2138790038 @default.
- W50021174 hasRelatedWork W2254636873 @default.
- W50021174 hasRelatedWork W2254964763 @default.
- W50021174 hasRelatedWork W2265179222 @default.
- W50021174 hasRelatedWork W2291717155 @default.
- W50021174 hasRelatedWork W2323723092 @default.
- W50021174 hasRelatedWork W2343963422 @default.
- W50021174 hasRelatedWork W2358732098 @default.
- W50021174 hasRelatedWork W2394769471 @default.
- W50021174 hasRelatedWork W2411452470 @default.
- W50021174 hasRelatedWork W2418885657 @default.
- W50021174 hasRelatedWork W2485003203 @default.
- W50021174 isParatext "false" @default.
- W50021174 isRetracted "false" @default.
- W50021174 magId "50021174" @default.
- W50021174 workType "article" @default.