Matches in SemOpenAlex for { <https://semopenalex.org/work/W5002502> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W5002502 endingPage "513" @default.
- W5002502 startingPage "499" @default.
- W5002502 abstract "Six subjects with normal renal function (NRF) and 6 patients with minimal renal function (MRF) on 3 times weekly hemodialysis received 150 µCi 3H-digoxin-l2α orally. Serial urine collections were made for five days or more. Digoxin and metabolites were separated using diethylaminoethyl Sephadex LH-20 column chromatography. Mean cumulative percentages of the ingested radioactivity excreted over five days in NRF and MRF groups were: digoxin, 54.5% and 14.7%; bis-digitoxoside of digoxigenin, 2.0% and 0.50%; mono-digitoxoside, 0.8% and 0.19%; digoxigenin, 0.25% and 0.03%; and dihydrodigoxin, 0.3% and 0.03%. Half-lives based on the mean rates of disappearance from urine comparing NRF and MRF groups were: for digoxin, 40 hr and 120 hr; for bis-digitoxoside, 11.5 hr and 46 hr; for mono-digitoxoside, 8.5 hr and 12 hr; for digoxigenin, 2 hr and 7.5 hr; and for dihydrodigoxin, 1.2 hr and 7.0 hr. Considering the relationships of the five-day cumulative excretion and half-lives of digoxin and metabolites in the NRF and MRF groups, it appears unlikely that there is a major alteration in the biotransformation of digoxin in advanced renal failure when there appears to be a shift from renal to slower biliary excretion." @default.
- W5002502 created "2016-06-24" @default.
- W5002502 creator A5023650753 @default.
- W5002502 creator A5044669337 @default.
- W5002502 creator A5056152968 @default.
- W5002502 creator A5060353221 @default.
- W5002502 creator A5082834848 @default.
- W5002502 date "1979-05-01" @default.
- W5002502 modified "2023-10-14" @default.
- W5002502 title "Biotransformation and elimination of digoxin with normal and minimal renal function" @default.
- W5002502 doi "https://doi.org/10.1002/cpt1979255part1499" @default.
- W5002502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/436354" @default.
- W5002502 hasPublicationYear "1979" @default.
- W5002502 type Work @default.
- W5002502 sameAs 5002502 @default.
- W5002502 citedByCount "41" @default.
- W5002502 countsByYear W50025022014 @default.
- W5002502 crossrefType "journal-article" @default.
- W5002502 hasAuthorship W5002502A5023650753 @default.
- W5002502 hasAuthorship W5002502A5044669337 @default.
- W5002502 hasAuthorship W5002502A5056152968 @default.
- W5002502 hasAuthorship W5002502A5060353221 @default.
- W5002502 hasAuthorship W5002502A5082834848 @default.
- W5002502 hasConcept C10146269 @default.
- W5002502 hasConcept C104317684 @default.
- W5002502 hasConcept C126322002 @default.
- W5002502 hasConcept C134018914 @default.
- W5002502 hasConcept C150194340 @default.
- W5002502 hasConcept C159641895 @default.
- W5002502 hasConcept C163994747 @default.
- W5002502 hasConcept C181199279 @default.
- W5002502 hasConcept C185592680 @default.
- W5002502 hasConcept C2776552150 @default.
- W5002502 hasConcept C2777707475 @default.
- W5002502 hasConcept C2778198053 @default.
- W5002502 hasConcept C2779547328 @default.
- W5002502 hasConcept C2780026642 @default.
- W5002502 hasConcept C2780091579 @default.
- W5002502 hasConcept C27881333 @default.
- W5002502 hasConcept C43617362 @default.
- W5002502 hasConcept C55493867 @default.
- W5002502 hasConcept C71924100 @default.
- W5002502 hasConcept C81439078 @default.
- W5002502 hasConceptScore W5002502C10146269 @default.
- W5002502 hasConceptScore W5002502C104317684 @default.
- W5002502 hasConceptScore W5002502C126322002 @default.
- W5002502 hasConceptScore W5002502C134018914 @default.
- W5002502 hasConceptScore W5002502C150194340 @default.
- W5002502 hasConceptScore W5002502C159641895 @default.
- W5002502 hasConceptScore W5002502C163994747 @default.
- W5002502 hasConceptScore W5002502C181199279 @default.
- W5002502 hasConceptScore W5002502C185592680 @default.
- W5002502 hasConceptScore W5002502C2776552150 @default.
- W5002502 hasConceptScore W5002502C2777707475 @default.
- W5002502 hasConceptScore W5002502C2778198053 @default.
- W5002502 hasConceptScore W5002502C2779547328 @default.
- W5002502 hasConceptScore W5002502C2780026642 @default.
- W5002502 hasConceptScore W5002502C2780091579 @default.
- W5002502 hasConceptScore W5002502C27881333 @default.
- W5002502 hasConceptScore W5002502C43617362 @default.
- W5002502 hasConceptScore W5002502C55493867 @default.
- W5002502 hasConceptScore W5002502C71924100 @default.
- W5002502 hasConceptScore W5002502C81439078 @default.
- W5002502 hasIssue "5part1" @default.
- W5002502 hasLocation W50025021 @default.
- W5002502 hasLocation W50025022 @default.
- W5002502 hasOpenAccess W5002502 @default.
- W5002502 hasPrimaryLocation W50025021 @default.
- W5002502 hasRelatedWork W1993617885 @default.
- W5002502 hasRelatedWork W2036863687 @default.
- W5002502 hasRelatedWork W2039700748 @default.
- W5002502 hasRelatedWork W2042033030 @default.
- W5002502 hasRelatedWork W2059373368 @default.
- W5002502 hasRelatedWork W2093166709 @default.
- W5002502 hasRelatedWork W2127085070 @default.
- W5002502 hasRelatedWork W2443684673 @default.
- W5002502 hasRelatedWork W2748952813 @default.
- W5002502 hasRelatedWork W5002502 @default.
- W5002502 hasVolume "25" @default.
- W5002502 isParatext "false" @default.
- W5002502 isRetracted "false" @default.
- W5002502 magId "5002502" @default.
- W5002502 workType "article" @default.