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- W50041904 abstract "Nucleotide excision repair (excision repair) is a general repair system for damaged (modified) bases. It is considered the repair system for bulky adducts, but it is also capable of eliminating all base lesions, big or small, from DNA. Damage removal is accomplished by dual incisions bracketing the lesion by a multisubunit enzyme system referred to as excision nuclease or excinuclease. The prokaryotic excinuclease incises the 8th phosphodiester bond 5′ and the 4th or 5th phosphodiester bond 3′ to the lesion and thus excises the damaged nucleotide(s) in 12- to 13-nucleotide-long oligomers (Sancar and Rupp 1983). The human excinuclease incises the 22nd phosphodiester bond 5′ and the 4th to 6th phosphodiester bond 3′ to the damaged nucleotide(s) and releases the damage in 27- to 29-nucleotide-long oligomers (Huang et al. 1992). Following excision the resulting gap is filled and ligated by DNA polymerases and ligases. In contrast to the excision step the gap filling step, which is referred to as repair synthesis, is carried out by proteins whose primary function is replication. Hence, defect in the repair synthesis step is usually a side effect of a more general problem in cellular physiology." @default.
- W50041904 created "2016-06-24" @default.
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- W50041904 date "1998-01-01" @default.
- W50041904 modified "2023-09-25" @default.
- W50041904 title "Nucleotide Excision Repair in Man" @default.
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- W50041904 doi "https://doi.org/10.1007/978-3-642-48770-5_7" @default.
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