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- W50065678 abstract "This study investigated the effects of Trypanosoma brucei infection on post-partum (PP) uterine involution in the albino rat (Rattus norvegicus). Ninety-six rats (80 females and 16 males) were used for the study. The females were divided into 2 equal groups of 40 infected and 40 uninfected. The males which were uninfected were used for mating with the females. From each of the 2 female groups, 5 were humanely sacrifi ced daily from day 0 to day 7 PP. Body mass (BM), uterine mass (UM), uterine mass as a percentage of body mass (UMPBM), uterine histomorphology, packed cell volume (PCV), level of parasitaemia (LOP) and rectal temperature (RT) were evaluated in the females. Results showed that both the UM and the UMPBM of the infected rats were signifi cantly higher (P<0.01) than those of the uninfected between days 1 and 7 PP. Uterine histomorphology showed that between days 3 and 7 PP, involution was more advanced in the uninfected group. Uterine sections of the infected rats had more glands, which were also larger in size. Endometrial stroma was less cellular in the uninfected rats and the myometrium showed higher nuclei density for myofi brils, which suggests some loss of cytoplasm. The PCV of the infected rats was signifi cantly lower than that of the uninfected (P<0.01) between days 9 and 14 post-infection (PI), while the RT of the infected rats was signifi cantly higher (P<0.01) than that of the uninfected between days 5 and 14 PI. It was therefore concluded that T. brucei infection led to a signifi cant delay in PP uterine involution, as evidenced by the higher UM and UMPBM, and the uterine histomorphological fi ndings in the infected rats." @default.
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- W50065678 date "2013-01-01" @default.
- W50065678 modified "2023-09-26" @default.
- W50065678 title "The effects of Trypanosoma brucei infection on post-partum uterine involution." @default.
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