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- W5015925 abstract "96 mice of the RIII strain of brother-to-sister matings were treated and observed throughout life. 24 female mice 6 1/2-months-old were given .2 mgm doses of progesterone by sc injection over a 4-month period. A mouse which had received .6 mgm of progesterone developed mammary carcinoma 3 weeks after starting therapy. Another mouse having received 1.6 mg of progesterone developed a similar tumor after 8 weeks and a 3rd mouse after 2.2 mgm of progesterone developed mammary cancer 11 weeks after the 1st injection. A mammary tumor appeared in a 4th mouse 2 months after injections were discontinued. The sc injection of progesterone alone had reduced the incidence of adenocarcinoma of the mammary glands from 54% in controls to 16.6% in treated mice. Of 48 mice treated with both progesterone and testosterone propionate only 3 (6.2%) developed mammary cancer the progesterone acting as an adjuvant. Histologic findings suggest that the effects of the 2 hormones are obscure. The hormones had no inhibitory effect on already established mammary cancer. Spayed females injected with both testosterone and progesterone did not develop any mammary cancers although both control and injected mice lived 16-24 months. A sarcoma of the jaw developed in 1 mouse apparently a fortuitous occurrence. The injection of testosterone propionate and progesterone is suggested as a prophylactic measure in women with family history of breast cancer." @default.
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- W5015925 date "1945-07-01" @default.
- W5015925 modified "2023-09-24" @default.
- W5015925 title "The Effect of Progesterone and Testosterone Propionate on the Incidence of Mammary Cancer in Mice" @default.
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