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• W50161146 abstract "This chapter describes method for the measurement of triiodothyronine (T3) in human serum. In a study described in the chapter, the sensitivity was sufficient for the determinations on hypothyroid and normal and thyrotoxic sera. The values obtained were in reasonable agreement with a double isotope derivative assay. The normal T3 concentration in human serum approximates 0.2 μg per 100 ml; the mean ± SD of 31 normal sera was 220 ± 27 nanograms (ng) per 100 ml. Appropriate elevations were observed in sera from 40 patients with thyro toxicosis, and diminutions were found in sera from 10 hypothyroid patients. In rare instances, thyrotoxicosis may be a cause of elevated serum T3 with normal thyroxine (T4) concentration. The incidence of this condition remains to be determined. In about half the cases with low serum T4 after 131I therapy, the eumetabolic state may be maintained by normal or elevated T3 concentration. From these data and kinetic studies indicating a rapid turnover, it may be inferred that T3 rather than T4 is the more important hormone in health and in disease. The normal daily fractional turnover of T3 is approximately half of its extrathyroidal pool, in contrast to the T4 turnover of 10% per day. The apparent volume of T3 distribution (43 liters) is 4–5 times that of T4." @default.
• W50161146 created "2016-06-24" @default.
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• W50161146 date "1970-01-01" @default.
• W50161146 modified "2023-09-26" @default.
• W50161146 title "The Significance of Circulating Triiodothyronine" @default.
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• W50161146 doi "https://doi.org/10.1016/b978-0-12-571126-5.50010-8" @default.
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