Matches in SemOpenAlex for { <https://semopenalex.org/work/W50207746> ?p ?o ?g. }
Showing items 1 to 66 of
66
with 100 items per page.
- W50207746 abstract "Prostanoids such as prostaglandins (PGs) and thromboxane (TXA{sub 2}) are a family of oxygenated metabolites of arachidonic acid. They produce a wide variety of physiological and pathophysiological effects mediated through specific cell surface receptors. Recent cDNA cloning of the prostaglandins and thromboxane receptors indicates that they are a unique family of receptors within the superfamily of G-protein-coupled receptors. Not only are all the prostanoids (PGE{sub 2}, PGF{sub 2{alpha}}, PGI{sub 2}, PGD{sub 2} and TXA{sub 2}) structurally related, but their receptors also show significant (26-47%) amino acid sequence identity. To investigate the evolutionary relationship between the various prostanoid receptors and their involvement in a number of pathophysiological conditions, we have mapped these loci in the human genome. The PGE{sub 2} receptor subtypes Ep{sub 1}, EP{sub 2}, EP{sub 3}, the PGF{sub 2{alpha}} receptor (FP), the PGI{sub 2} receptor (IP) and the TXA{sub 2} receptor (Tbxa2r) were sublocalized by in situ hybridization. EP{sub 1},IP and Tbxa2r were mapped to chromosome 19 at 19p13.1, 19q13.3 and 19p13.3, respectively. EP{sub 3} and FP mapped to 1p13.2 and 1p13.1, respectively. EP{sub 2} mapped to 5p13.1. Mapping the genomic loci of the prostanoid receptor family genes should expand our understanding of the evolution of G-protein-coupled receptor familymore » genes and advance our investigation of the involvement of these genes in various pathophysiological conditions.« less" @default.
- W50207746 created "2016-06-24" @default.
- W50207746 creator A5056063220 @default.
- W50207746 creator A5075281834 @default.
- W50207746 creator A5087959395 @default.
- W50207746 date "1994-09-01" @default.
- W50207746 modified "2023-09-23" @default.
- W50207746 title "Chromosomal localization of prostanoid receptor genes" @default.
- W50207746 hasPublicationYear "1994" @default.
- W50207746 type Work @default.
- W50207746 sameAs 50207746 @default.
- W50207746 citedByCount "0" @default.
- W50207746 crossrefType "journal-article" @default.
- W50207746 hasAuthorship W50207746A5056063220 @default.
- W50207746 hasAuthorship W50207746A5075281834 @default.
- W50207746 hasAuthorship W50207746A5087959395 @default.
- W50207746 hasConcept C104317684 @default.
- W50207746 hasConcept C134018914 @default.
- W50207746 hasConcept C170493617 @default.
- W50207746 hasConcept C203014093 @default.
- W50207746 hasConcept C2776785769 @default.
- W50207746 hasConcept C2778266237 @default.
- W50207746 hasConcept C2781024287 @default.
- W50207746 hasConcept C51603380 @default.
- W50207746 hasConcept C54355233 @default.
- W50207746 hasConcept C86803240 @default.
- W50207746 hasConcept C89560881 @default.
- W50207746 hasConceptScore W50207746C104317684 @default.
- W50207746 hasConceptScore W50207746C134018914 @default.
- W50207746 hasConceptScore W50207746C170493617 @default.
- W50207746 hasConceptScore W50207746C203014093 @default.
- W50207746 hasConceptScore W50207746C2776785769 @default.
- W50207746 hasConceptScore W50207746C2778266237 @default.
- W50207746 hasConceptScore W50207746C2781024287 @default.
- W50207746 hasConceptScore W50207746C51603380 @default.
- W50207746 hasConceptScore W50207746C54355233 @default.
- W50207746 hasConceptScore W50207746C86803240 @default.
- W50207746 hasConceptScore W50207746C89560881 @default.
- W50207746 hasLocation W502077461 @default.
- W50207746 hasOpenAccess W50207746 @default.
- W50207746 hasPrimaryLocation W502077461 @default.
- W50207746 hasRelatedWork W114417019 @default.
- W50207746 hasRelatedWork W128581850 @default.
- W50207746 hasRelatedWork W1729808602 @default.
- W50207746 hasRelatedWork W1992833721 @default.
- W50207746 hasRelatedWork W2007270755 @default.
- W50207746 hasRelatedWork W2033866105 @default.
- W50207746 hasRelatedWork W2034292992 @default.
- W50207746 hasRelatedWork W2060862790 @default.
- W50207746 hasRelatedWork W2072002920 @default.
- W50207746 hasRelatedWork W2083995394 @default.
- W50207746 hasRelatedWork W2098878979 @default.
- W50207746 hasRelatedWork W2137871129 @default.
- W50207746 hasRelatedWork W2162312300 @default.
- W50207746 hasRelatedWork W2335892884 @default.
- W50207746 hasRelatedWork W2413676473 @default.
- W50207746 hasRelatedWork W2419088265 @default.
- W50207746 hasRelatedWork W2601859320 @default.
- W50207746 hasRelatedWork W2741881335 @default.
- W50207746 hasRelatedWork W3098052237 @default.
- W50207746 hasRelatedWork W2826254678 @default.
- W50207746 hasVolume "55" @default.
- W50207746 isParatext "false" @default.
- W50207746 isRetracted "false" @default.
- W50207746 magId "50207746" @default.
- W50207746 workType "article" @default.