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- W5024375 abstract "Abstract Defining the minimum essential vaccine components required for protective immunity to HIV and FIV remains a major challenge. A recent study reported that recombinant HIV-1 capsid p24 vaccines conferred cross-protection against FIV in cats. Current studies were performed to confirm this protection and identify other protective HIV/FIV proteins. Pathogen-free cats were immunized 3X with HIV p24 (CA), HIV p66 (reverse transcriptase RT), FIV p24, FIV p66, FIV p15 (matrix MA), or combination in adjuvant (plus LPS/IL-12), and were challenged 3 wk later with FIV. Infection was monitored by immunoblot for FIV antibodies, and by FIV RT and PCR tests of lymphoid cells. Cellular immunity was monitored by virus-specific IFN-γ ELISPOT and CFSE-based proliferation of T cells. Protection rates were 2/8 cats for HIV p24, 2/8 HIV p24+p66, 3/7 HIV p66, 1/8 FIV p24, 0/3 FIV p15, 2/7 FIV p24+p66, 5/7 FIV p66, 2/4 HIV p24+FIV p66, and 0/8 adjuvant or PBS. Vaccinated cats had strong IFN-γ and CD4/CD8-CFSE responses to HIV or FIV peptides, but developed no virus neutralizing antibodies. Combined protection rates for current and previous studies are 40/64 cats for HIV p24, 4/25 FIV p24, 5/7 FIV p66, 3/7 HIV p66, 0/3 FIV p15, 0/22 adjuvant, and 0/37 PBS. Thus, cross-protective immunity between HIV-1 and FIV is achievable, and selection of vaccine proteins and epitopes based on structural homology that risk viral fitness is an effective strategy." @default.
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- W5024375 date "2009-04-01" @default.
- W5024375 modified "2023-09-26" @default.
- W5024375 title "Efficacy of HIV-1 and FIV subunit vaccines against FIV (132.3)" @default.
- W5024375 doi "https://doi.org/10.4049/jimmunol.182.supp.132.3" @default.
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