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- W50355955 abstract "Total suppression of righting reflex in frogs (Rana pipiens, 25-35 mg b.w.) was observed after combined administration of melatonin (12.5 mg/kg) and selective inhibitors of MAO-A: clorgyline (2.5 mg/kg) and moclobemide (50 mg/kg) but not MAO-B: selegiline (25 mg/kg) and Ro-19-6327 (50 mg/kg). None of these drugs alone affected the righting reflex. Clorgyline and selegiline selectively inhibited brain MAO-A and MAO-B activity (by more than 90%), resp. Frogs might represent a convenient model to study the selective MAO-A and B type inhibitors since they provide the opportunity to correlate behaviour and biochemical changes induced by MAO inhibitors." @default.
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- W50355955 date "1994-01-01" @default.
- W50355955 modified "2023-09-27" @default.
- W50355955 title "Synergistic sedative effect of selective MAO-A, but not MAO-B, inhibitors and melatonin in frogs" @default.
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- W50355955 doi "https://doi.org/10.1007/978-3-7091-9324-2_19" @default.
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