Matches in SemOpenAlex for { <https://semopenalex.org/work/W5040294> ?p ?o ?g. }
- W5040294 endingPage "131" @default.
- W5040294 startingPage "101" @default.
- W5040294 abstract "The choroid plexus (CP) of the blood-CSF barrier (BCSFB) displays fundamentally different properties than blood-brain barrier (BBB). With brisk blood flow (10 × brain) and highly permeable capillaries, the human CP provides the CNS with a high turnover rate of fluid (∼400,000 μL/day) containing micronutrients, peptides, and hormones for neuronal networks. Renal-like basement membranes in microvessel walls and underneath the epithelium filter large proteins such as ferritin and immunoglobulins. Type IV collagen (α3, α4, and α5) in the subepithelial basement membrane confers kidney-like permselectivity. As in the glomerulus, so also in CP, the basolateral membrane utrophin A and colocalized dystrophin impart structural stability, transmembrane signaling, and ion/water homeostasis. Extensive infoldings of the plasma-facing basal labyrinth together with lush microvilli at the CSF-facing membrane afford surface area, as great as that at BBB, for epithelial solute and water exchange. CSF formation occurs by basolateral carrier-mediated uptake of Na+, Cl-, and HCO3-, followed by apical release via ion channel conductance and osmotic flow of water through AQP1 channels. Transcellular epithelial active transport and secretion are energized and channeled via a highly dense organelle network of mitochondria, endoplasmic reticulum, and Golgi; bleb formation occurs at the CSF surface. Claudin-2 in tight junctions helps to modulate the lower electrical resistance and greater permeability in CP than at BBB. Still, ratio analyses of influx coefficients (Kin) for radiolabeled solutes indicate that paracellular diffusion of small nonelectrolytes (e.g., urea and mannitol) through tight junctions is restricted; molecular sieving is proportional to solute size. Protein/peptide movement across BCSFB is greatly limited, occurring by paracellular leaks through incomplete tight junctions and low-capacity transcellular pinocytosis/exocytosis. Steady-state concentration ratios, CSF/plasma, ranging from 0.003 for IgG to 0.80 for urea, provide insight on plasma solute penetrability, barrier permeability, and CSF sink action to clear substances from CNS." @default.
- W5040294 created "2016-06-24" @default.
- W5040294 creator A5051241259 @default.
- W5040294 creator A5054773576 @default.
- W5040294 creator A5082937125 @default.
- W5040294 date "2010-11-12" @default.
- W5040294 modified "2023-10-12" @default.
- W5040294 title "The Blood–Cerebrospinal Fluid Barrier: Structure and Functional Significance" @default.
- W5040294 cites W1246015656 @default.
- W5040294 cites W1540331610 @default.
- W5040294 cites W1604922098 @default.
- W5040294 cites W1791620864 @default.
- W5040294 cites W1898796296 @default.
- W5040294 cites W1964592615 @default.
- W5040294 cites W1967790293 @default.
- W5040294 cites W1970305385 @default.
- W5040294 cites W1971034255 @default.
- W5040294 cites W1973613551 @default.
- W5040294 cites W1979158135 @default.
- W5040294 cites W1979192270 @default.
- W5040294 cites W1981425827 @default.
- W5040294 cites W1981544624 @default.
- W5040294 cites W1983411033 @default.
- W5040294 cites W1983688519 @default.
- W5040294 cites W1984481886 @default.
- W5040294 cites W1986179029 @default.
- W5040294 cites W1986970678 @default.
- W5040294 cites W1989355785 @default.
- W5040294 cites W1989821271 @default.
- W5040294 cites W1990283560 @default.
- W5040294 cites W1992451772 @default.
- W5040294 cites W1993023886 @default.
- W5040294 cites W1997340271 @default.
- W5040294 cites W1998567477 @default.
- W5040294 cites W2000845808 @default.
- W5040294 cites W2007182518 @default.
- W5040294 cites W2007352722 @default.
- W5040294 cites W2015829066 @default.
- W5040294 cites W2016815899 @default.
- W5040294 cites W2017037574 @default.
- W5040294 cites W2018014306 @default.
- W5040294 cites W2018051124 @default.
- W5040294 cites W2020849388 @default.
- W5040294 cites W2021050960 @default.
- W5040294 cites W2021391478 @default.
- W5040294 cites W2021544788 @default.
- W5040294 cites W2021651525 @default.
- W5040294 cites W2022906574 @default.
- W5040294 cites W2025826061 @default.
- W5040294 cites W2027892007 @default.
- W5040294 cites W2028832993 @default.
- W5040294 cites W2031759209 @default.
- W5040294 cites W2036610870 @default.
- W5040294 cites W2043709580 @default.
- W5040294 cites W2044353913 @default.
- W5040294 cites W2044661831 @default.
- W5040294 cites W2044913442 @default.
- W5040294 cites W2045530566 @default.
- W5040294 cites W2045820243 @default.
- W5040294 cites W2046610391 @default.
- W5040294 cites W2046941779 @default.
- W5040294 cites W2048185125 @default.
- W5040294 cites W2049226316 @default.
- W5040294 cites W2051150474 @default.
- W5040294 cites W2052679565 @default.
- W5040294 cites W2052971108 @default.
- W5040294 cites W2054220545 @default.
- W5040294 cites W2054889018 @default.
- W5040294 cites W2056351891 @default.
- W5040294 cites W2057226095 @default.
- W5040294 cites W2057842421 @default.
- W5040294 cites W2066957527 @default.
- W5040294 cites W2068368267 @default.
- W5040294 cites W2069139878 @default.
- W5040294 cites W2071818990 @default.
- W5040294 cites W2072994989 @default.
- W5040294 cites W2073569103 @default.
- W5040294 cites W2075603129 @default.
- W5040294 cites W2076652901 @default.
- W5040294 cites W2076996133 @default.
- W5040294 cites W2078299794 @default.
- W5040294 cites W2079891083 @default.
- W5040294 cites W2081765246 @default.
- W5040294 cites W2081796154 @default.
- W5040294 cites W2082288818 @default.
- W5040294 cites W2082399023 @default.
- W5040294 cites W2082739856 @default.
- W5040294 cites W2084123893 @default.
- W5040294 cites W2084612470 @default.
- W5040294 cites W2085528006 @default.
- W5040294 cites W2087657303 @default.
- W5040294 cites W2087666006 @default.
- W5040294 cites W2091880490 @default.
- W5040294 cites W2092193387 @default.
- W5040294 cites W2094705715 @default.
- W5040294 cites W2095323362 @default.
- W5040294 cites W2096730504 @default.
- W5040294 cites W2096964291 @default.