FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W50468539> ?p ?o ?g. }

• W50468539 endingPage "227" @default.
• W50468539 startingPage "197" @default.
• W50468539 abstract "Terpenoids, also referred to as terpenes, are the largest group of natural compounds. Many terpenes have biological activities and are used for the treatment of human diseases. The worldwide sales of terpene-based pharmaceuticals in 2002 were approximately US $12 billion. Among these pharmaceuticals, the anticancer drug Taxol® and the antimalarial drug Artimesinin are two of the most renowned terpene-based drugs. All terpenoids are synthesized from two five-carbon building blocks. Based on the number of the building blocks, terpenoids are commonly classified as monoterpenes (C10), sesquiterpenes (C15), diterpenes (C20), and sesterterpenes (C25). These terpenoids display a wide range of biological activities against cancer, malaria, inflammation, and a variety of infectious diseases (viral and bacterial). In last two decades, natural-product bioprospecting from the marine environment has resulted in hundreds of terpenoids with novel structures and interesting bioactivities, with more to be discovered in the future. The problem of supply is a serious obstacle to the development of most terpenoid compounds with interesting pharmaceutical properties. Although total chemical synthesis plays a less important role in the production of some terpenoid drugs, it has contributed significantly to the development of terpenoid compounds and terpene-based drugs by providing critical information on structure-activity relationships (SAR) and chiral centers as well as generating analog libraries. Semisynthesis, on the other hand, has played a major role in the development and production of terpenoid-derived drugs. Metabolic engineering as an integrated bioengineering approach has made considerable progress to produce some terpenoids in plants and fermentable hosts. Cell culture and aquaculture will provide a solution for the supply issue of some valuable terpenes from terrestrial and marine environments, respectively. Recent advances in environmental genomics and other “-omics” technologies will facilitate isolation and discovery of new terpenoids from natural environments. There is no doubt that more terpenoid-based clinical drugs will become available and will play a more significant role in human disease treatment in the near future." @default.
• W50468539 created "2016-06-24" @default.
• W50468539 creator A5015400701 @default.
• W50468539 creator A5053760788 @default.
• W50468539 creator A5087354808 @default.
• W50468539 date "2007-11-17" @default.
• W50468539 modified "2023-10-03" @default.
• W50468539 title "Terpenoids As Therapeutic Drugs and Pharmaceutical Agents" @default.
• W50468539 cites W140864706 @default.
• W50468539 cites W1483551254 @default.
• W50468539 cites W1522954291 @default.
• W50468539 cites W1527930169 @default.
• W50468539 cites W1575716997 @default.
• W50468539 cites W1583923863 @default.
• W50468539 cites W1591187753 @default.
• W50468539 cites W1618474788 @default.
• W50468539 cites W178931966 @default.
• W50468539 cites W1908283262 @default.
• W50468539 cites W1928700421 @default.
• W50468539 cites W1963921910 @default.
• W50468539 cites W1965332656 @default.
• W50468539 cites W1965370520 @default.
• W50468539 cites W1965416028 @default.
• W50468539 cites W1966647123 @default.
• W50468539 cites W1968926226 @default.
• W50468539 cites W1969790953 @default.
• W50468539 cites W1970092103 @default.
• W50468539 cites W1970326538 @default.
• W50468539 cites W1971299193 @default.
• W50468539 cites W1972401663 @default.
• W50468539 cites W1972613941 @default.
• W50468539 cites W1973472019 @default.
• W50468539 cites W1975128985 @default.
• W50468539 cites W1975533327 @default.
• W50468539 cites W1975688780 @default.
• W50468539 cites W1975778782 @default.
• W50468539 cites W1976866675 @default.
• W50468539 cites W1981686319 @default.
• W50468539 cites W1984075558 @default.
• W50468539 cites W1985310665 @default.
• W50468539 cites W1985858069 @default.
• W50468539 cites W1987614704 @default.
• W50468539 cites W1988065886 @default.
• W50468539 cites W1989027386 @default.
• W50468539 cites W1989468261 @default.
• W50468539 cites W1990052017 @default.
• W50468539 cites W1991960380 @default.
• W50468539 cites W1992060534 @default.
• W50468539 cites W1992930941 @default.
• W50468539 cites W1993054253 @default.
• W50468539 cites W1994104858 @default.
• W50468539 cites W1996465436 @default.
• W50468539 cites W1997638680 @default.
• W50468539 cites W2000912127 @default.
• W50468539 cites W2004070151 @default.
• W50468539 cites W2004516927 @default.
• W50468539 cites W2004846059 @default.
• W50468539 cites W2006925660 @default.
• W50468539 cites W2007974642 @default.
• W50468539 cites W2008290167 @default.
• W50468539 cites W2010482780 @default.
• W50468539 cites W2010678436 @default.
• W50468539 cites W2012119848 @default.
• W50468539 cites W2013400562 @default.
• W50468539 cites W2015572460 @default.
• W50468539 cites W2016042364 @default.
• W50468539 cites W2017192757 @default.
• W50468539 cites W2018120830 @default.
• W50468539 cites W2018967387 @default.
• W50468539 cites W2020026562 @default.
• W50468539 cites W2020257939 @default.
• W50468539 cites W2020472025 @default.
• W50468539 cites W2024383044 @default.
• W50468539 cites W2024734917 @default.
• W50468539 cites W2025999444 @default.
• W50468539 cites W2026844309 @default.
• W50468539 cites W2028254177 @default.
• W50468539 cites W2029525329 @default.
• W50468539 cites W2029993303 @default.
• W50468539 cites W2030541098 @default.
• W50468539 cites W2032022146 @default.
• W50468539 cites W2032574998 @default.
• W50468539 cites W2033384774 @default.
• W50468539 cites W2033746214 @default.
• W50468539 cites W2035183545 @default.
• W50468539 cites W2036886024 @default.
• W50468539 cites W2037107834 @default.
• W50468539 cites W2037490361 @default.
• W50468539 cites W2037672318 @default.
• W50468539 cites W2037866233 @default.
• W50468539 cites W2039056796 @default.
• W50468539 cites W2039647828 @default.
• W50468539 cites W2041163647 @default.
• W50468539 cites W2044256186 @default.
• W50468539 cites W2044444420 @default.
• W50468539 cites W2044458543 @default.
• W50468539 cites W2046739879 @default.
• W50468539 cites W2047090399 @default.

• next