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- W50488754 abstract "Fibroblast Growth Factors (FGFs), a family of signalling molecules, are involved in several developmental processes. In the developing chick limb FGFs play a role in outgrowth, differentiation and cell death. A specialised thickening of cells known as the Apical Ectodermal Ridge (AER) produces certain FGFs that signal to the underlying mesencymal cells. This interaction results in the maintenance of a region of undifferentiated proliferating mesenchyme cells at the tip of the limb bud. Pyst1/MKP3, a predominantly cytosolic, dual specificity (Thr/Tyr) MAPK phosphatase, is expressed at sites of FGF8/FGFR1 signalling in mouse (Dickinson et al. 2002) and chick embryos. I have tested whether expression of Pyst1/MKP3 is regulated by FGFs produced by the AER in the chick embryos and using specific inhibitors, I have investigated which intracellular signal transduction pathways are involved." @default.
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- W50488754 date "2002-11-01" @default.
- W50488754 modified "2023-09-26" @default.
- W50488754 title "5 Pyst1/MKP3, a novel dual-specificity phosphatase, and FGF signalling in chick limb development." @default.
- W50488754 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1570983" @default.
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