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- W5051796 abstract "A mikroszomalis glukoz-6-foszfat transzporter extrahepatikus nem glukoneogenetikus sejt-tipusokban tortenő manifesztacioit vizsgalva kimutattuk a feherje jelenletet es funkciojat human granulocitakban es patkany epididimalis zsirszovetben. Eredmenyeink alapjan valoszinűsithető, hogy a nem-glukoneogenetikus szovetekben a transzporter legfontosabb feladata a hexoz-6-foszfat dehidrogenaz szubsztratellatasa, s igy az intraluminalis pentoz foszfat ciklusban a NADPH generalasa. A NADPH termeles celja lehet egyreszt az antioxidans homeosztazis fenntartasa (granulocita), vagy a 11β-hidroxiszteroid dehidrogenaz 1-es tipusanak kofaktor ellatasa (maj, zsirszovet) s ennek reven reszvetel a kortizon termelesben. Az eredmenyekből kovetkezően a glukoz-6-foszfat transzporter es a hexoz-6-foszfat dehidrogenaz fontos terapias celpont lehet a metabolikus szindroma gyogyszeres kezeleseben. | The presence and function of the microsomal glucose-6-phosphate transporter was investigated in certain non gluconeogenic cell-types, such as human granulocytes and rat epidydymal adipose tissues. Based on our observations the substrate supply for the hexose-6-phosphate dehydrogenase and this way the generation of NADPH in the intralumenal pentose- phosphate pathway is one of the main tasks of the transporter. Thus NADPH production can participate in the maintenance of the antioxidant homeostasis in granulocytes, or in liver and adipose tissues it can contribute to the cofactor supply for the 11β-hydroxysteroid dehydrogenase type 1 and this way it is involved in cortisone production. It is suggested that glucose-6-phosphate transporter and hexose-6-phosphate dehydrogenase are potential therapeutic targets in treatment of the metabolic syndrome." @default.
- W5051796 created "2016-06-24" @default.
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- W5051796 date "2006-01-01" @default.
- W5051796 modified "2023-10-12" @default.
- W5051796 title "A glukóz-6-foszfatáz rendszer extrahepatikus megjelenésének patofiziológiai szerepe = The pathophysiological role of the extrahepatic manifestations of glucose-6-phosphatase system" @default.
- W5051796 hasPublicationYear "2006" @default.
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