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- W50532413 abstract "Gliomas are the most frequent malignant intracranial tumors arising from the brain or spinal cord tissue. The most malignant among them is glioblastoma multiforme (GBM), which constitutes approximately 20–25% of all primary intracranial neoplasms with an incidence of 3–4/100,000. This type of tumor is characterized by progressive overgrowth of neoplastic glial cells with widespread and relentless invasion, resulting in acquisition of resistance to treatment and a poor prognosis due to recurrence. These features hamper efficient surgical intervention of the disease. Current chemo/radiotherapy conditions act sublethally but cannot effectively suppress the proliferation of glioma cells. Despite some progress, the therapeutic options are yet limited, and novel therapeutic strategies are clearly needed. Targeting of disease-specific molecules involved in the proliferation, apoptosis, and invasion of the tumor cells as well as in tumor angiogenesis may offer a high potential for the development of more effective therapies for GBM. RNA interference (RNAi) has been emerging not only for in vitro target validation, but also for a novel therapeutic strategy based on the highly specific and efficient silencing of a target gene. Indeed, RNAi has shown to act against GBM efficiently in numerous preclinical studies. Many efforts have been devoted to overcome the three major obstacles in use of RNAi in vivo; their specificity, instability, and poor cellular delivery of bioactive small interfering RNA (siRNA) across the blood–brain barrier. The identification of effective target and the establishment of novel siRNA delivery systems are needed for the clinical applications of RNAi for treatment of GBM." @default.
- W50532413 created "2016-06-24" @default.
- W50532413 creator A5003551381 @default.
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- W50532413 creator A5074654484 @default.
- W50532413 date "2010-01-01" @default.
- W50532413 modified "2023-09-26" @default.
- W50532413 title "RNAi in Malignant Brain Tumors: Relevance to Molecular and Translational Research" @default.
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