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- W50558279 abstract "EnterohemorrhagicEscherichia coli (EHEC) causes a variety of clinical conditions, the most important being hemorrhagic colitis and hemolytic uremic syndrome. A curative therapy of EHEC diseases is not yet feasible. This study investigates the antibody reactivity of Lactobin®, a standardized immunoglobulin (Ig) preparation, obtained from the colostra of non-immunized cows. Three different batches of Lactobin® exhibited equally high titers of specific antibodies againstShiga-like toxins (SLTs, verocytotoxins) and EHEC hemolysin (EHEC-Hly) produced byE. coli O157. In addition, Lactobin® blocked the cytotoxic effect of SLT-I and SLT-II on Vero cell monolayers and inhibited the cytolytic effects of EHEC-Hly on human erythrocytes. Since Lactobin® contains high levels of antibodies and neutralizing activity against important virulence factors of EHEC O157, this drug has potential use in the treatment of diarrhea and the prevention of EHEC-associated hemolytic uremic syndrome." @default.
- W50558279 created "2016-06-24" @default.
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- W50558279 date "1996-09-01" @default.
- W50558279 modified "2023-09-23" @default.
- W50558279 title "A standard immunoglobulin preparation produced from bovine colostra shows antibody reactivity and neutralization activity againstShiga-like toxins and EHEC-hemolysin ofEscherichia coli O157:H7" @default.
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- W50558279 doi "https://doi.org/10.1007/bf01716084" @default.
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