Matches in SemOpenAlex for { <https://semopenalex.org/work/W50592810> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W50592810 endingPage "234" @default.
- W50592810 startingPage "231" @default.
- W50592810 abstract "Treosulfan is a bifunctional alkylating prodrug with activity against various solid tumors. To improve the outcome for patients with recurrent malignant glioma, we assessed the efficacy of intravenous treosulfan (6-10 g/m2 4-weekly) as salvage therapy for patients with recurrent or progressive glioblastoma (GB, n = 14) or anaplastic astrocytoma (AA, n = 2). All patients had prior involved-field radiotherapy and adjuvant nitrosourea-based chemotherapy. A total of 56 cycles were administered. Tumor responses were assessed radiologically and clinically prior to each cycle. All patients were assessable for toxicity, response and survival. There were no complete or partial responses (CR, PR). Two patients progressed after the first cycle, 14 patients had initially stable disease (SD). Median progression-free survival was 3.25 months for the GB patients. Five patients were progression-free at 6 months (30%), including the 2 AA patients. The 2 AA patients are stable at 22 months. Myelosuppression was the dose-limiting toxicity in this cohort of nitrosourea-pretreated patients. Treosulfan has modest activity in patients with recurrent malignant glioma. Further evaluation of treosulfan in chemonaive malignant glioma patients is warranted." @default.
- W50592810 created "2016-06-24" @default.
- W50592810 creator A5017177249 @default.
- W50592810 creator A5047708132 @default.
- W50592810 creator A5066290988 @default.
- W50592810 creator A5080392503 @default.
- W50592810 creator A5080482957 @default.
- W50592810 date "2000-01-01" @default.
- W50592810 modified "2023-10-11" @default.
- W50592810 cites W1858161324 @default.
- W50592810 cites W1959628099 @default.
- W50592810 cites W2000963380 @default.
- W50592810 cites W2007510198 @default.
- W50592810 cites W2019042500 @default.
- W50592810 cites W2264385870 @default.
- W50592810 cites W90206776 @default.
- W50592810 doi "https://doi.org/10.1023/a:1006496831144" @default.
- W50592810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11212902" @default.
- W50592810 hasPublicationYear "2000" @default.
- W50592810 type Work @default.
- W50592810 sameAs 50592810 @default.
- W50592810 citedByCount "12" @default.
- W50592810 countsByYear W505928102014 @default.
- W50592810 countsByYear W505928102015 @default.
- W50592810 countsByYear W505928102016 @default.
- W50592810 crossrefType "journal-article" @default.
- W50592810 hasAuthorship W50592810A5017177249 @default.
- W50592810 hasAuthorship W50592810A5047708132 @default.
- W50592810 hasAuthorship W50592810A5066290988 @default.
- W50592810 hasAuthorship W50592810A5080392503 @default.
- W50592810 hasAuthorship W50592810A5080482957 @default.
- W50592810 hasBestOaLocation W505928101 @default.
- W50592810 hasConcept C126322002 @default.
- W50592810 hasConcept C141071460 @default.
- W50592810 hasConcept C143998085 @default.
- W50592810 hasConcept C2776694085 @default.
- W50592810 hasConcept C2776755627 @default.
- W50592810 hasConcept C2776946711 @default.
- W50592810 hasConcept C2778227246 @default.
- W50592810 hasConcept C2778880634 @default.
- W50592810 hasConcept C2779083369 @default.
- W50592810 hasConcept C2779178397 @default.
- W50592810 hasConcept C2780611847 @default.
- W50592810 hasConcept C29730261 @default.
- W50592810 hasConcept C502942594 @default.
- W50592810 hasConcept C509974204 @default.
- W50592810 hasConcept C71924100 @default.
- W50592810 hasConcept C90924648 @default.
- W50592810 hasConceptScore W50592810C126322002 @default.
- W50592810 hasConceptScore W50592810C141071460 @default.
- W50592810 hasConceptScore W50592810C143998085 @default.
- W50592810 hasConceptScore W50592810C2776694085 @default.
- W50592810 hasConceptScore W50592810C2776755627 @default.
- W50592810 hasConceptScore W50592810C2776946711 @default.
- W50592810 hasConceptScore W50592810C2778227246 @default.
- W50592810 hasConceptScore W50592810C2778880634 @default.
- W50592810 hasConceptScore W50592810C2779083369 @default.
- W50592810 hasConceptScore W50592810C2779178397 @default.
- W50592810 hasConceptScore W50592810C2780611847 @default.
- W50592810 hasConceptScore W50592810C29730261 @default.
- W50592810 hasConceptScore W50592810C502942594 @default.
- W50592810 hasConceptScore W50592810C509974204 @default.
- W50592810 hasConceptScore W50592810C71924100 @default.
- W50592810 hasConceptScore W50592810C90924648 @default.
- W50592810 hasIssue "3" @default.
- W50592810 hasLocation W505928101 @default.
- W50592810 hasLocation W505928102 @default.
- W50592810 hasOpenAccess W50592810 @default.
- W50592810 hasPrimaryLocation W505928101 @default.
- W50592810 hasRelatedWork W1993636025 @default.
- W50592810 hasRelatedWork W1997541085 @default.
- W50592810 hasRelatedWork W2025336893 @default.
- W50592810 hasRelatedWork W2034447818 @default.
- W50592810 hasRelatedWork W2134390770 @default.
- W50592810 hasRelatedWork W2158789712 @default.
- W50592810 hasRelatedWork W2347438058 @default.
- W50592810 hasRelatedWork W2404042595 @default.
- W50592810 hasRelatedWork W2440255802 @default.
- W50592810 hasRelatedWork W59994307 @default.
- W50592810 hasVolume "49" @default.
- W50592810 isParatext "false" @default.
- W50592810 isRetracted "false" @default.
- W50592810 magId "50592810" @default.
- W50592810 workType "article" @default.