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- W50781698 abstract "This chapter examines the augmented binding of tumor cells by activated murine macrophages and its relevance to tumor cytotoxicity. Macrophages activated by a variety of infectious agents are able to destroy tumor cells efficiently in vitro. Macrophage-mediated cytotoxicity is target selective, as neoplastically transformed cells are lysed in preference to their nontransformed counterparts. Both microscopic and cine-microscopic observations of activated MΦ-tumor cell cultures have further revealed clustering of activated MΦ about tumor cells that are lysed. Macrophages activated in a variety of ways in vivo and in vitro selectively bind neoplastic targets to an augmented degree. The augmented binding, which is inhibited by plasma membranes of tumor cells, is saturable, competitively inhibitable, and dependent upon trypsinsensitive surface components and has two functional consequences, which include cytolysis of the bound targets and secretion of a lytic proteinase. The augmented binding, thus, has many characteristics of the specific interaction between ligand and receptor. The low-level binding seen between numerous cell pairs in culture has many characteristics of nonspecific binding. The capacity for augmented binding is mediated by receptors on the macrophages for structures contained within the plasma membranes of neoplastic cells." @default.
- W50781698 created "2016-06-24" @default.
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- W50781698 date "1982-01-01" @default.
- W50781698 modified "2023-09-25" @default.
- W50781698 title "AUGMENTED BINDING OF TUMOR CELLS BY ACTIVATED MURINE MACROPHAGES AND ITS RELEVANCE TO TUMOR CYTOTOXICITY" @default.
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- W50781698 doi "https://doi.org/10.1016/b978-0-12-341360-4.50149-9" @default.
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