Matches in SemOpenAlex for { <https://semopenalex.org/work/W50782754> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W50782754 endingPage "222" @default.
- W50782754 startingPage "213" @default.
- W50782754 abstract "Transgenic murine models of cardiovascular disease offer great potential insights regarding mechanisms of human disease, but efficient and reliable methods for phenotype evaluation are necessary. We employed non-invasive echocardiography to evaluate hemodynamic parameters in mice, and evaluated statistical reliability of these parameters with respect to anesthesia regimen. Male CF-1 mice received inhaled halothane (0.25-0.75% in 95% O2) or ketamine/xylazine (80/10 mg/kg i.p.) and 2-dimensional, M-mode, and Doppler ultrasound imaging were used to assess cardiac contractility and aortic flow velocities. Halothane was more convenient and reliable with respect to rate of induction, reversal, and control of anesthetic depth. At comparable levels of anesthesia, ketamine/xylazine produced significant reductions in heart rate (308 +/- 14 vs. 501 +/- 14 bpm, p<0.001), left ventricular fractional shortening (41.7 +/- 1.3 vs. 49.3 +/- 1.0%, p<0.001), and cardiac output (7.6 +/- 0.5 vs. 11.5 +/- 0.6 ml/min, p<0.001) when compared to halothane inhalation. No change in stroke volume or peak aortic velocity was observed. Correlation analyses revealed highly significant positive relationships between heart rate and fractional shortening (r=0.61, p<0.002) and cardiac output (r=0.88, p<0.001) but no relation to stroke volume or aortic velocity. Variability of intra-animal and intragroup parameter estimation were frequently 2-fold larger for ketamine/xylazine anesthesia vs. halothane. Statistical power analysis showed the increased measurement error for ketamine/xylazine leads to much larger numbers of mice/group to achieve identical statistical sensitivity. These data further illustrate the feasibility of echocardiography for rapid, non-invasive cardiovascular assessment in mice. However, several obtainable parameters are highly sensitive to both heart rate and anesthetic used and the choice and control of anesthetic are critical for physiologically relevant performance parameters and maximal ability to detect statistical differences among groups. Thus, for these non-invasive studies, inhalation anesthesia with agents such as halothane is superior to anesthesia induced by ketamine/xylazine administration." @default.
- W50782754 created "2016-06-24" @default.
- W50782754 creator A5010989605 @default.
- W50782754 creator A5013857042 @default.
- W50782754 creator A5081822113 @default.
- W50782754 date "2001-06-01" @default.
- W50782754 modified "2023-09-29" @default.
- W50782754 title "Non-invasive echocardiographic studies in mice" @default.
- W50782754 doi "https://doi.org/10.1016/s0024-3205(01)01123-7" @default.
- W50782754 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11441911" @default.
- W50782754 hasPublicationYear "2001" @default.
- W50782754 type Work @default.
- W50782754 sameAs 50782754 @default.
- W50782754 citedByCount "81" @default.
- W50782754 countsByYear W507827542012 @default.
- W50782754 countsByYear W507827542013 @default.
- W50782754 countsByYear W507827542014 @default.
- W50782754 countsByYear W507827542015 @default.
- W50782754 countsByYear W507827542016 @default.
- W50782754 countsByYear W507827542019 @default.
- W50782754 countsByYear W507827542022 @default.
- W50782754 countsByYear W507827542023 @default.
- W50782754 crossrefType "journal-article" @default.
- W50782754 hasAuthorship W50782754A5010989605 @default.
- W50782754 hasAuthorship W50782754A5013857042 @default.
- W50782754 hasAuthorship W50782754A5081822113 @default.
- W50782754 hasConcept C126322002 @default.
- W50782754 hasConcept C139940330 @default.
- W50782754 hasConcept C164705383 @default.
- W50782754 hasConcept C178853913 @default.
- W50782754 hasConcept C2776359302 @default.
- W50782754 hasConcept C2776932660 @default.
- W50782754 hasConcept C2777953023 @default.
- W50782754 hasConcept C2778162923 @default.
- W50782754 hasConcept C2779591255 @default.
- W50782754 hasConcept C2780795376 @default.
- W50782754 hasConcept C39133596 @default.
- W50782754 hasConcept C42219234 @default.
- W50782754 hasConcept C71924100 @default.
- W50782754 hasConcept C80461066 @default.
- W50782754 hasConcept C84393581 @default.
- W50782754 hasConceptScore W50782754C126322002 @default.
- W50782754 hasConceptScore W50782754C139940330 @default.
- W50782754 hasConceptScore W50782754C164705383 @default.
- W50782754 hasConceptScore W50782754C178853913 @default.
- W50782754 hasConceptScore W50782754C2776359302 @default.
- W50782754 hasConceptScore W50782754C2776932660 @default.
- W50782754 hasConceptScore W50782754C2777953023 @default.
- W50782754 hasConceptScore W50782754C2778162923 @default.
- W50782754 hasConceptScore W50782754C2779591255 @default.
- W50782754 hasConceptScore W50782754C2780795376 @default.
- W50782754 hasConceptScore W50782754C39133596 @default.
- W50782754 hasConceptScore W50782754C42219234 @default.
- W50782754 hasConceptScore W50782754C71924100 @default.
- W50782754 hasConceptScore W50782754C80461066 @default.
- W50782754 hasConceptScore W50782754C84393581 @default.
- W50782754 hasIssue "2" @default.
- W50782754 hasLocation W507827541 @default.
- W50782754 hasLocation W507827542 @default.
- W50782754 hasOpenAccess W50782754 @default.
- W50782754 hasPrimaryLocation W507827541 @default.
- W50782754 hasRelatedWork W1967079908 @default.
- W50782754 hasRelatedWork W1967778834 @default.
- W50782754 hasRelatedWork W2018940375 @default.
- W50782754 hasRelatedWork W2048024095 @default.
- W50782754 hasRelatedWork W2322288739 @default.
- W50782754 hasRelatedWork W2889757952 @default.
- W50782754 hasRelatedWork W3026007890 @default.
- W50782754 hasRelatedWork W3089939402 @default.
- W50782754 hasRelatedWork W4817160 @default.
- W50782754 hasRelatedWork W50782754 @default.
- W50782754 hasVolume "69" @default.
- W50782754 isParatext "false" @default.
- W50782754 isRetracted "false" @default.
- W50782754 magId "50782754" @default.
- W50782754 workType "article" @default.