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- W50869372 abstract "The underlying mechanism of the degradation of articular cartilage is an imbalance between anabolic and catabolic pathways, which are under the control of cytokines. Chemokines are a novel class of small cytokines and have a wide range of effects in many different cell types, both inside and outside of the immune system. Their actions are mediated by a family of 7-transmembrane G-protein-coupled receptors. Recent studies have demonstrated that chondrocytes co-express chemokines and their receptors, and that the interaction of chemokines with their receptors results in the release of cartilage matrix-degrading proteinases, and affect proteoglycan metabolism in chondrocytes. These data reveal a catabolic pathway primed by chemokine/chemokine receptor system in articular cartilage, thus proposing a novel therapeutic approach against cartilage destruction in arthropathy." @default.
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- W50869372 date "2001-12-01" @default.
- W50869372 modified "2023-09-29" @default.
- W50869372 title "Role of chemokines/chemokine receptor systems in cartilage degradation." @default.
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