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- W50871686 abstract "Maspin (SerpinB5), a serine protease inhibitor, is putatively regarded as a tumour suppressor. Its expression is epigenetically silenced in many tumours. Loss of Maspin expression is related to tumour progression. Maspin inhibits angiogenesis. The RSL (reactive site loop) of Maspin is the major determinant of its effects on cell adhesion, migration and apoptosis, but probably not angiogenesis. The binding of p53 to the Maspin promoter implicates p53 in the suppression of cell proliferation. Suppression of Maspin may activate EMT. Maspin may also influence ER/PR signalling." @default.
- W50871686 created "2016-06-24" @default.
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- W50871686 date "2013-01-01" @default.
- W50871686 modified "2023-09-28" @default.
- W50871686 title "Maspin (SerpinB5)" @default.
- W50871686 doi "https://doi.org/10.1016/b978-0-12-416570-0.00019-6" @default.
- W50871686 hasPublicationYear "2013" @default.
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