FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W50896875> ?p ?o ?g. }

• W50896875 endingPage "3709" @default.
• W50896875 startingPage "3701" @default.
• W50896875 abstract "Abstract The human blood coagulation factor VIII C2 domain (Ser2173-Tyr2332) contains an epitope recognized by most polyclonal inhibitory anti-factor VIII alloantibodies and autoantibodies. We took advantage of the differential reactivity of inhibitory antibodies with human and porcine factor VIII and mapped a major determinant of the C2 epitope by using a series of active recombinant hybrid human/porcine factor VIII molecules. A series of five C2-specific human antibodies and a murine anti-factor VIII monoclonal antibody, NMC-VIII/5, inhibited a hybrid containing a substitution of porcine sequence for Glu2181-Val2243 significantly less than human factor VIII. In contrast, four of the five patient antibodies and NMC-VIII/5 inhibited a hybrid containing a substitution of porcine sequence for Thr2253-Tyr2332 equally well as human factor VIII. Thus, a major factor VIII inhibitor epitope determinant is bounded by Glu2181-Val2243 at the NH2-terminal end of the C2 domain. Because C2 inhibitors block the binding of factor VIII to phospholipid and von Willebrand factor, for which binding sites have been localized to Thr2303-Tyr2332, these results imply that the segment bounded by Glu2181-Val2243 also is involved in these macromolecular interactions." @default.
• W50896875 created "2016-06-24" @default.
• W50896875 creator A5013298828 @default.
• W50896875 creator A5017307924 @default.
• W50896875 creator A5039153828 @default.
• W50896875 creator A5053387578 @default.
• W50896875 creator A5055094271 @default.
• W50896875 creator A5072410798 @default.
• W50896875 creator A5084448921 @default.
• W50896875 date "1998-11-15" @default.
• W50896875 modified "2023-09-26" @default.
• W50896875 title "Residues Glu2181-Val2243 Contain a Major Determinant of the Inhibitory Epitope in the C2 Domain of Human Factor VIII" @default.
• W50896875 cites W118880679 @default.
• W50896875 cites W1427181771 @default.
• W50896875 cites W1482422136 @default.
• W50896875 cites W1497014448 @default.
• W50896875 cites W1512481003 @default.
• W50896875 cites W1537233497 @default.
• W50896875 cites W1539663343 @default.
• W50896875 cites W1548584593 @default.
• W50896875 cites W1564224388 @default.
• W50896875 cites W1564299213 @default.
• W50896875 cites W1578596706 @default.
• W50896875 cites W1599606526 @default.
• W50896875 cites W1608541477 @default.
• W50896875 cites W1741259868 @default.
• W50896875 cites W1745001432 @default.
• W50896875 cites W1967104104 @default.
• W50896875 cites W1977048225 @default.
• W50896875 cites W1977971077 @default.
• W50896875 cites W1986705405 @default.
• W50896875 cites W2004593736 @default.
• W50896875 cites W2005268147 @default.
• W50896875 cites W2015599673 @default.
• W50896875 cites W2021283345 @default.
• W50896875 cites W2025227827 @default.
• W50896875 cites W2027217170 @default.
• W50896875 cites W2038030714 @default.
• W50896875 cites W2049786448 @default.
• W50896875 cites W2051487926 @default.
• W50896875 cites W2054616813 @default.
• W50896875 cites W2075248695 @default.
• W50896875 cites W2091641615 @default.
• W50896875 cites W2093056397 @default.
• W50896875 cites W2109711122 @default.
• W50896875 cites W2148113183 @default.
• W50896875 cites W2181469541 @default.
• W50896875 cites W2278120109 @default.
• W50896875 cites W2310992830 @default.
• W50896875 cites W2337912069 @default.
• W50896875 cites W2343495727 @default.
• W50896875 cites W2468628651 @default.
• W50896875 cites W2494708045 @default.
• W50896875 cites W261754042 @default.
• W50896875 cites W262805330 @default.
• W50896875 cites W264789688 @default.
• W50896875 cites W4256252711 @default.
• W50896875 cites W4294216491 @default.
• W50896875 cites W4297820747 @default.
• W50896875 doi "https://doi.org/10.1182/blood.v92.10.3701" @default.
• W50896875 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9808564" @default.
• W50896875 hasPublicationYear "1998" @default.
• W50896875 type Work @default.
• W50896875 sameAs 50896875 @default.
• W50896875 citedByCount "77" @default.
• W50896875 countsByYear W508968752012 @default.
• W50896875 countsByYear W508968752013 @default.
• W50896875 countsByYear W508968752015 @default.
• W50896875 countsByYear W508968752016 @default.
• W50896875 countsByYear W508968752017 @default.
• W50896875 countsByYear W508968752018 @default.
• W50896875 countsByYear W508968752019 @default.
• W50896875 countsByYear W508968752020 @default.
• W50896875 countsByYear W508968752022 @default.
• W50896875 crossrefType "journal-article" @default.
• W50896875 hasAuthorship W50896875A5013298828 @default.
• W50896875 hasAuthorship W50896875A5017307924 @default.
• W50896875 hasAuthorship W50896875A5039153828 @default.
• W50896875 hasAuthorship W50896875A5053387578 @default.
• W50896875 hasAuthorship W50896875A5055094271 @default.
• W50896875 hasAuthorship W50896875A5072410798 @default.
• W50896875 hasAuthorship W50896875A5084448921 @default.
• W50896875 hasConcept C104317684 @default.
• W50896875 hasConcept C143840085 @default.
• W50896875 hasConcept C153911025 @default.
• W50896875 hasConcept C159654299 @default.
• W50896875 hasConcept C185592680 @default.
• W50896875 hasConcept C195616568 @default.
• W50896875 hasConcept C203014093 @default.
• W50896875 hasConcept C2779394231 @default.
• W50896875 hasConcept C2781241564 @default.
• W50896875 hasConcept C40767141 @default.
• W50896875 hasConcept C41625074 @default.
• W50896875 hasConcept C542903549 @default.
• W50896875 hasConcept C55493867 @default.
• W50896875 hasConcept C86803240 @default.
• W50896875 hasConcept C89560881 @default.
• W50896875 hasConcept C956191 @default.

• next