Matches in SemOpenAlex for { <https://semopenalex.org/work/W50949008> ?p ?o ?g. }
- W50949008 endingPage "102" @default.
- W50949008 startingPage "89" @default.
- W50949008 abstract "Inflammatory cells are thought to be instrumental in the pathophysiology of diseases and the control of their recruitment and activation appears to be an attractive strategy for therapeutic intervention. Chemokines are a family of small molecular weight (7–15 kDa) proteins that in conjunction with adhesion molecules play a crucial role in leukocyte recruitment, cellular activation and proliferation at sites of inflammation. Chemokines are produced by a variety of cell types, including leukocytic and non-leukocytic cells, usually in response to antigens, irritants and other cytokines. Interleukin-8 (CXCL8) was the first member to be identified of this new family of proinflammatory chemokines that now constitute over 45 members. Chemokines produce their biological effects by interacting with greater than 18 G protein coupled cell surface receptors. A few chemokines bind selectively to a single receptor but other chemokines bind to more than one receptor [1, 2]. CXCL8 belongs to a subgroup of chemokines known as ELR+ chemokines because of the Glu4-Leu5-Arg6 amino acid sequence between positions 4 and 6. Other members of this group include CXCL1, 2, 3, 5, 6, and 7. A diverse variety of biological effects are attributed to CXCL8 and related ELR+ chemokines, including several involving inflammatory cell activation and chemotaxis, production of reactive oxygen species, increased expression of the integrin CD11b-CD18, enhancement of cell adhesion to endothelial cells, promotion of angiogenesis, modulation of histamine and lipid mediator release as well as azurophil granule release [3]." @default.
- W50949008 created "2016-06-24" @default.
- W50949008 creator A5007588400 @default.
- W50949008 creator A5025569634 @default.
- W50949008 date "2007-08-07" @default.
- W50949008 modified "2023-09-23" @default.
- W50949008 title "IL-8 receptor antagonist: basic research and clinical utility" @default.
- W50949008 cites W1495127214 @default.
- W50949008 cites W1514277024 @default.
- W50949008 cites W1542204592 @default.
- W50949008 cites W1564674105 @default.
- W50949008 cites W1571619727 @default.
- W50949008 cites W1581404300 @default.
- W50949008 cites W1595430911 @default.
- W50949008 cites W179370715 @default.
- W50949008 cites W1980271166 @default.
- W50949008 cites W1981836658 @default.
- W50949008 cites W1989688291 @default.
- W50949008 cites W1989787685 @default.
- W50949008 cites W1990674750 @default.
- W50949008 cites W1996620001 @default.
- W50949008 cites W1998218749 @default.
- W50949008 cites W2004946548 @default.
- W50949008 cites W2006303725 @default.
- W50949008 cites W2008218015 @default.
- W50949008 cites W2014971932 @default.
- W50949008 cites W2016927483 @default.
- W50949008 cites W2017105217 @default.
- W50949008 cites W2017345251 @default.
- W50949008 cites W2022921865 @default.
- W50949008 cites W2024699319 @default.
- W50949008 cites W2024940131 @default.
- W50949008 cites W2035570125 @default.
- W50949008 cites W2043684255 @default.
- W50949008 cites W2046618178 @default.
- W50949008 cites W2050431219 @default.
- W50949008 cites W2052023212 @default.
- W50949008 cites W2053517795 @default.
- W50949008 cites W2057022448 @default.
- W50949008 cites W2057434635 @default.
- W50949008 cites W2057896496 @default.
- W50949008 cites W2059807289 @default.
- W50949008 cites W2063270450 @default.
- W50949008 cites W2064217869 @default.
- W50949008 cites W2065470359 @default.
- W50949008 cites W2066032007 @default.
- W50949008 cites W2066880035 @default.
- W50949008 cites W2074318777 @default.
- W50949008 cites W2075621476 @default.
- W50949008 cites W2081989923 @default.
- W50949008 cites W2083340333 @default.
- W50949008 cites W2088069551 @default.
- W50949008 cites W2092816381 @default.
- W50949008 cites W2093511814 @default.
- W50949008 cites W2097029238 @default.
- W50949008 cites W2100582080 @default.
- W50949008 cites W2108983987 @default.
- W50949008 cites W2109663505 @default.
- W50949008 cites W2112652806 @default.
- W50949008 cites W2117792412 @default.
- W50949008 cites W2133189461 @default.
- W50949008 cites W2134055933 @default.
- W50949008 cites W2135377650 @default.
- W50949008 cites W2136836360 @default.
- W50949008 cites W2143330341 @default.
- W50949008 cites W2153532735 @default.
- W50949008 cites W2157568924 @default.
- W50949008 cites W2158549296 @default.
- W50949008 cites W2162525617 @default.
- W50949008 cites W2164401185 @default.
- W50949008 cites W2169594043 @default.
- W50949008 cites W2170749916 @default.
- W50949008 cites W2181039132 @default.
- W50949008 cites W2949417238 @default.
- W50949008 cites W4229906281 @default.
- W50949008 cites W4296792904 @default.
- W50949008 cites W990932059 @default.
- W50949008 doi "https://doi.org/10.1007/978-3-7643-7437-2_7" @default.
- W50949008 hasPublicationYear "2007" @default.
- W50949008 type Work @default.
- W50949008 sameAs 50949008 @default.
- W50949008 citedByCount "1" @default.
- W50949008 countsByYear W509490082014 @default.
- W50949008 crossrefType "book-chapter" @default.
- W50949008 hasAuthorship W50949008A5007588400 @default.
- W50949008 hasAuthorship W50949008A5025569634 @default.
- W50949008 hasConcept C13373296 @default.
- W50949008 hasConcept C16224149 @default.
- W50949008 hasConcept C164027704 @default.
- W50949008 hasConcept C185592680 @default.
- W50949008 hasConcept C203014093 @default.
- W50949008 hasConcept C2776914184 @default.
- W50949008 hasConcept C86803240 @default.
- W50949008 hasConcept C95444343 @default.
- W50949008 hasConcept C96525457 @default.
- W50949008 hasConceptScore W50949008C13373296 @default.
- W50949008 hasConceptScore W50949008C16224149 @default.
- W50949008 hasConceptScore W50949008C164027704 @default.