Matches in SemOpenAlex for { <https://semopenalex.org/work/W51111220> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W51111220 endingPage "7" @default.
- W51111220 startingPage "2581" @default.
- W51111220 abstract "To evaluate the effect of drug ionization on the ocular hypotensive activity of topical carbonic anhydrase inhibitors.Ocular normotensive New Zealand albino and ocular hypertensive Dutch Belted pigmented rabbits were used. Tonometric intraocular pressure levels were taken after topical application of 50 microliters of drug (at various concentrations and pH values) to one eye with the contralateral eye used as an untreated control. The drugs tested were MK-927, L-662,583, and AHR-16329. Eye tissues were analyzed for drug by our enzymatic methods.In all cases, the more ionized the applied drug the greater the ocular hypotensive activity. Tissue distribution studies showed that there was more drug found in the eye after the ionized form of a drug was applied than that found after application of the less ionized forms.Increasing the ionization of three ampholyte topical carbonic anhydrase inhibitors increases their ocular hypotensive activity. These data taken with ocular disposition data suggest that ionized compounds of this type are more readily sequestered in the cornea, which serves as a drug depot for prolonged drug delivery and activity." @default.
- W51111220 created "2016-06-24" @default.
- W51111220 creator A5025514143 @default.
- W51111220 creator A5037012715 @default.
- W51111220 date "1993-07-01" @default.
- W51111220 modified "2023-09-23" @default.
- W51111220 title "pH and drug ionization affects ocular pressure lowering of topical carbonic anhydrase inhibitors." @default.
- W51111220 cites W120733322 @default.
- W51111220 cites W1231951729 @default.
- W51111220 cites W1966971943 @default.
- W51111220 cites W1974896920 @default.
- W51111220 cites W1980648696 @default.
- W51111220 cites W1991925819 @default.
- W51111220 cites W2003699480 @default.
- W51111220 cites W2004949350 @default.
- W51111220 cites W2045076124 @default.
- W51111220 cites W2066368129 @default.
- W51111220 cites W2083391311 @default.
- W51111220 cites W2101371043 @default.
- W51111220 cites W2152427099 @default.
- W51111220 cites W2269927988 @default.
- W51111220 cites W73049795 @default.
- W51111220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8325759" @default.
- W51111220 hasPublicationYear "1993" @default.
- W51111220 type Work @default.
- W51111220 sameAs 51111220 @default.
- W51111220 citedByCount "8" @default.
- W51111220 countsByYear W511112202012 @default.
- W51111220 countsByYear W511112202018 @default.
- W51111220 crossrefType "journal-article" @default.
- W51111220 hasAuthorship W51111220A5025514143 @default.
- W51111220 hasAuthorship W51111220A5037012715 @default.
- W51111220 hasConcept C118487528 @default.
- W51111220 hasConcept C181199279 @default.
- W51111220 hasConcept C185592680 @default.
- W51111220 hasConcept C2775914622 @default.
- W51111220 hasConcept C2776882836 @default.
- W51111220 hasConcept C2777405951 @default.
- W51111220 hasConcept C2778076468 @default.
- W51111220 hasConcept C2780035454 @default.
- W51111220 hasConcept C2781092963 @default.
- W51111220 hasConcept C42219234 @default.
- W51111220 hasConcept C55493867 @default.
- W51111220 hasConcept C71924100 @default.
- W51111220 hasConcept C98274493 @default.
- W51111220 hasConceptScore W51111220C118487528 @default.
- W51111220 hasConceptScore W51111220C181199279 @default.
- W51111220 hasConceptScore W51111220C185592680 @default.
- W51111220 hasConceptScore W51111220C2775914622 @default.
- W51111220 hasConceptScore W51111220C2776882836 @default.
- W51111220 hasConceptScore W51111220C2777405951 @default.
- W51111220 hasConceptScore W51111220C2778076468 @default.
- W51111220 hasConceptScore W51111220C2780035454 @default.
- W51111220 hasConceptScore W51111220C2781092963 @default.
- W51111220 hasConceptScore W51111220C42219234 @default.
- W51111220 hasConceptScore W51111220C55493867 @default.
- W51111220 hasConceptScore W51111220C71924100 @default.
- W51111220 hasConceptScore W51111220C98274493 @default.
- W51111220 hasIssue "8" @default.
- W51111220 hasLocation W511112201 @default.
- W51111220 hasOpenAccess W51111220 @default.
- W51111220 hasPrimaryLocation W511112201 @default.
- W51111220 hasRelatedWork W176484652 @default.
- W51111220 hasRelatedWork W1999193613 @default.
- W51111220 hasRelatedWork W2023544933 @default.
- W51111220 hasRelatedWork W2040280159 @default.
- W51111220 hasRelatedWork W2040460961 @default.
- W51111220 hasRelatedWork W2045076124 @default.
- W51111220 hasRelatedWork W2059957468 @default.
- W51111220 hasRelatedWork W2064663836 @default.
- W51111220 hasRelatedWork W51111220 @default.
- W51111220 hasRelatedWork W94455333 @default.
- W51111220 hasVolume "34" @default.
- W51111220 isParatext "false" @default.
- W51111220 isRetracted "false" @default.
- W51111220 magId "51111220" @default.
- W51111220 workType "article" @default.