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- W5111365 abstract "Neoplasms of plasma cells are a group of diseases characterized by the presence of clonal plasma cells in the bone marrow (BM). These entities are placed into a particular diagnostic category based on their overall clinical, laboratory, and pathological features. They range from a relatively common, asymptomatic disorder called monoclonal gammopathy of undetermined significance to the progressive and typically incurable disease of multiple myeloma (MM). Neoplastic plasma cells share many of the same morphological and immunophenotypic features of normal plasma cells. They also retain many of the same functions and activities including production of immunoglobulin (Ig) and accumulation in the BM. However, in plasma cell neoplasms, the derangement of these activities leads to the typical signs and symptoms of the disease. This includes cytopenias from BM failure, lytic skeletal lesions due to alterations of the BM microenvironment, monoclonal Ig in blood and urine, and, related to this, renal insufficiency due to glomerular Ig deposition. Over the last decade, there have been major advances in the treatment of MM including the introduction of whole new classes of drugs such as proteasome inhibitors and thalidomide-based immunomodulatory drugs. As such, patients now have multiple treatment options, whereas formerly, a BM transplant may have been the only hope. There have also been major advances in the understanding of the underlying pathophysiology and genetics, and this has enabled better classification and prognostication of patients. This article will review the clinical and pathological features, the diagnostic criteria, and the treatment of patients with plasma cell neoplasms." @default.
- W5111365 created "2016-06-24" @default.
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- W5111365 date "2014-01-01" @default.
- W5111365 modified "2023-10-14" @default.
- W5111365 title "Plasma Cell Neoplasms: MGUS and Myeloma" @default.
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- W5111365 doi "https://doi.org/10.1016/b978-0-12-386456-7.04109-5" @default.
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