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• W5113839 endingPage "83" @default.
• W5113839 startingPage "57" @default.
• W5113839 abstract "This study was undertaken to examine quantitatively the risks to human health posed by heterotrophic plate count (HPC) bacteria found naturally in ambient and potable waters. There is no clear-cut evidence that the HPC bacteria as a whole pose a public health risk. Only certain members are opportunistic pathogens. Using the four-tiered approach for risk assessment from the National Academy of Sciences, hazard identification, dose-response modeling, and exposure through ingestion of drinking water were evaluated to develop a risk characterization, which estimates the probability of infection for individuals consuming various levels of specific HPC bacteria. HPC bacteria in drinking water often include isolates from the following genera: Pseudomonas, Acinetobacter, Moraxella, Aeromonas, and Xanthomonas. Other bacteria that are commonly found are Legionella and Mycobacterium. All these genera contain species that are opportunistic pathogens which may cause serious diseases. For example, the three nonfermentative gram-negative rods most frequently isolated in the clinical laboratory are (1) Pseudomonas aeruginosa, (2) Acinetobacter, and (3) Xanthomonas maltophilia. P. aeruginosa is a major cause of hospital-acquired infections with a high mortality rate. Aeromonas is sometimes associated with wound infections and suspected to be a causative agent of diarrhea. Legionella pneumophila causes 4%-20% of cases of community-acquired pneumonia and has been ranked as the second or third most frequent cause of pneumonia requiring hospitalization. The number of cases of pulmonary disease associated with Mycobacterium avian is rapidly increasing and is approaching the incidence of M. tuberculosis in some areas. Moraxella can cause infections of the eye and upper respiratory tract. The oral infectious doses are as follows in animal and human test subjects: P. aeruginosa, 10(8)-10(9); A, hydrophila, > 10(10); M. avium, 10(4)-10(7); and X. maltophilia, 10(6)-10(9). The infectious dose for an opportunistic pathogen is lower for immunocompromised subjects or those on antibiotic treatment. These bacteria have been found in drinking water at the following frequencies: P. aeruginosa, < 1%-24%; Acinetobacter, 5%-38%; X. maltophilia, < 1%-2%; Aeromonas, 1%-27%; Moraxella, 10%-80%; M. avium, < 1%-50%; and L. pneumophila, 3%-33%. These data suggest that drinking water could be a source of infection for some of these bacteria. The risk characterization showed that risks of infection from oral ingestion ranged from a low of 7.3 x 10(-9) (7.3/billion) for low exposures to Aeromonas to higher risks predicted at high levels of exposure to Pseudomonas of 9 x 10(-2) (98/100). This higher risk was only predicted for individuals on antibiotics. Overall, the evidence suggests that specific members of HPC bacteria found in drinking water may be causative agents of both hospital- and community-acquired infections. However, the case numbers may be very low and the risks represent levels generally less than 1/10,000 for a single exposure to the bacterial agent. Future research needs include (1) determining the seasonal concentrations of these bacteria in drinking water, (2) conducting adequate dose-response studies in animal subjects or human volunteers, (3) determining the health risks for an individual with multiple exposures to the opportunistic pathogens, and (4) evaluating the increase in host susceptibility conferred by antibiotic use or immunosuppression." @default.
• W5113839 created "2016-06-24" @default.
• W5113839 creator A5008316952 @default.
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• W5113839 creator A5083906163 @default.
• W5113839 date "1997-01-01" @default.
• W5113839 modified "2023-10-17" @default.
• W5113839 title "Risk Assessment of Opportunistic Bacterial Pathogens in Drinking Water" @default.
• W5113839 cites W122250268 @default.
• W5113839 cites W134444516 @default.
• W5113839 cites W1483077637 @default.
• W5113839 cites W1485184635 @default.
• W5113839 cites W1499663263 @default.
• W5113839 cites W1501741496 @default.
• W5113839 cites W1508407524 @default.
• W5113839 cites W1534645421 @default.
• W5113839 cites W1553051904 @default.
• W5113839 cites W1570031151 @default.
• W5113839 cites W1570719233 @default.
• W5113839 cites W1591178683 @default.
• W5113839 cites W1595895264 @default.
• W5113839 cites W1726174962 @default.
• W5113839 cites W1741913991 @default.
• W5113839 cites W1771775187 @default.
• W5113839 cites W1907179548 @default.
• W5113839 cites W1914389557 @default.
• W5113839 cites W1937306455 @default.
• W5113839 cites W1944295005 @default.
• W5113839 cites W1951807997 @default.
• W5113839 cites W1951873137 @default.
• W5113839 cites W1954326829 @default.
• W5113839 cites W1963506312 @default.
• W5113839 cites W1966675671 @default.
• W5113839 cites W1968999800 @default.
• W5113839 cites W1970964835 @default.
• W5113839 cites W1972022120 @default.
• W5113839 cites W1973024085 @default.
• W5113839 cites W1976312367 @default.
• W5113839 cites W1980700706 @default.
• W5113839 cites W1981048868 @default.
• W5113839 cites W1984727640 @default.
• W5113839 cites W1999837368 @default.
• W5113839 cites W2000116738 @default.
• W5113839 cites W2000691548 @default.
• W5113839 cites W2002474210 @default.
• W5113839 cites W2002729605 @default.
• W5113839 cites W2005758646 @default.
• W5113839 cites W2009990134 @default.
• W5113839 cites W2010275843 @default.
• W5113839 cites W2011122371 @default.
• W5113839 cites W2020899103 @default.
• W5113839 cites W2022699462 @default.
• W5113839 cites W2024607245 @default.
• W5113839 cites W2030252455 @default.
• W5113839 cites W2031764924 @default.
• W5113839 cites W2037258506 @default.
• W5113839 cites W2038163624 @default.
• W5113839 cites W2039602526 @default.
• W5113839 cites W2043969503 @default.
• W5113839 cites W2045661576 @default.
• W5113839 cites W2048504001 @default.
• W5113839 cites W2050898414 @default.
• W5113839 cites W2058632028 @default.
• W5113839 cites W2058935222 @default.
• W5113839 cites W2064372479 @default.
• W5113839 cites W2065939111 @default.
• W5113839 cites W2068094897 @default.
• W5113839 cites W2071307438 @default.
• W5113839 cites W2073419778 @default.
• W5113839 cites W2075501409 @default.
• W5113839 cites W2077478739 @default.
• W5113839 cites W2078198067 @default.
• W5113839 cites W2078452955 @default.
• W5113839 cites W2083733667 @default.
• W5113839 cites W2087976919 @default.
• W5113839 cites W2091953741 @default.
• W5113839 cites W2100762885 @default.
• W5113839 cites W2101122522 @default.
• W5113839 cites W2101838792 @default.
• W5113839 cites W2109145139 @default.
• W5113839 cites W2112875552 @default.
• W5113839 cites W2117689688 @default.
• W5113839 cites W2124123964 @default.
• W5113839 cites W2139180069 @default.
• W5113839 cites W2142335592 @default.
• W5113839 cites W2142605800 @default.
• W5113839 cites W2146240351 @default.
• W5113839 cites W2147466355 @default.
• W5113839 cites W2154050620 @default.
• W5113839 cites W2164937608 @default.
• W5113839 cites W2165821732 @default.
• W5113839 cites W2167767021 @default.
• W5113839 cites W225365550 @default.
• W5113839 cites W2294913487 @default.
• W5113839 cites W2313499625 @default.
• W5113839 cites W2318545778 @default.
• W5113839 cites W2341862408 @default.

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