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- W51150360 abstract "This chapter presents purine ribonucleotide synthesis from purine bases and ribonucleosides. The significance of purine biosynthesis de novo was appreciated many years ago; however, it was not known until recently that cells could also utilize purine bases and nucleosides. The physiological significance of nucleotide and nucleic acid synthesis from purine bases was demonstrated by three types of evidence: (1) microorganisms were isolated that required one or more purine bases for growth, (2) inhibition of purine biosynthesis de novo with certain anticancer drugs resulted in only partial inhibition of tumor growth, and (3) genetic abnormalities in one of the enzymes of purine utilization led to severe neuropathy in children. However, the relative importance of purine base utilization and purine biosynthesis de novo varies greatly from one type of cell to another. Purine bases can be converted to ribonucleotides via phosphoribosyl-transferases; PP-ribose-P provides the ribosyl phosphate moiety." @default.
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- W51150360 date "1973-01-01" @default.
- W51150360 modified "2023-09-26" @default.
- W51150360 title "PURINE RIBONUCLEOTIDE SYNTHESIS FROM PURINE BASES AND RIBONUCLEOSIDES" @default.
- W51150360 doi "https://doi.org/10.1016/b978-0-12-340550-0.50014-9" @default.
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