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- W51244834 abstract "Allogeneic transplantation (allotransplantation) can cure a significant fraction of patients with high-risk or recurrent hematologic malignancies (1). However, this approach has been limited by the availability of suitable human leukocyte antigen (HLA)-matched related donors, and by the occurrence of severe graft-vs-host disease (GVHD) when bone marrow (BM) from HLA-matched unrelated donor (MUD), or partially HLA-mismatched family member grafts, are utilized (2–4). Attempts to reduce GVHD in recipients undergoing allotransplantation with MUD, or partially HLAmismatched family member grafts by T-cell depletion (TCD) has been shown to reduce acute GVHD. However, this benefit of reduced GVHD is offset by increases in the rates of graft failure, lymphoproliferative disorders associated with Epstein-Barr virus, and recurrent leukemia (5,6)." @default.
- W51244834 created "2016-06-24" @default.
- W51244834 creator A5059797628 @default.
- W51244834 date "2000-01-01" @default.
- W51244834 modified "2023-09-27" @default.
- W51244834 title "What Is an Accurate Risk/Benefit Ratio for Umbilical Cord Cell Transplantation in Children and Adults?" @default.
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- W51244834 doi "https://doi.org/10.1007/978-1-59259-657-7_3" @default.
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