Matches in SemOpenAlex for { <https://semopenalex.org/work/W51260818> ?p ?o ?g. }
- W51260818 endingPage "225" @default.
- W51260818 startingPage "199" @default.
- W51260818 abstract "A large number of RNA-binding proteins play critical roles in controlling eukaryotic gene expression at multiple RNA-processing steps. Many of these proteins have modular configuration, containing a RNA binding domain to recognize their target and functional module to affect RNA metabolism. This simple configuration motivated the design of artificial factors that specifically manipulate RNA. While significant progress has been made since 1990s to engineer DNA binding proteins with designed specificity, design of analogous RNA binding factors was not practical until recently. With the increasing complexity of biological pathways involving RNA regulation, engineering RNA binding factors with customized specificity and function has become an emerging field of research. Such factors can serve as novel method to manipulate RNA metabolism and thus are very useful in basic biological and medical research. Here we discuss the current advances in engineering RNA binding proteins, with emphasis on the design principles and their potential applications as new therapeutic reagents and basic biological tools." @default.
- W51260818 created "2016-06-24" @default.
- W51260818 creator A5020618435 @default.
- W51260818 creator A5066567153 @default.
- W51260818 date "2014-01-01" @default.
- W51260818 modified "2023-09-27" @default.
- W51260818 title "Manipulation of RNA Using Engineered Proteins with Customized Specificity" @default.
- W51260818 cites W1528632786 @default.
- W51260818 cites W1536595278 @default.
- W51260818 cites W1542686183 @default.
- W51260818 cites W1790543114 @default.
- W51260818 cites W183590699 @default.
- W51260818 cites W1964658455 @default.
- W51260818 cites W1964727443 @default.
- W51260818 cites W1965341424 @default.
- W51260818 cites W1967819482 @default.
- W51260818 cites W1968044187 @default.
- W51260818 cites W1969117624 @default.
- W51260818 cites W1970339917 @default.
- W51260818 cites W1971124068 @default.
- W51260818 cites W1978137506 @default.
- W51260818 cites W1982169734 @default.
- W51260818 cites W1982512914 @default.
- W51260818 cites W1982969769 @default.
- W51260818 cites W1984189327 @default.
- W51260818 cites W1984397453 @default.
- W51260818 cites W1986162480 @default.
- W51260818 cites W1987087374 @default.
- W51260818 cites W1987374058 @default.
- W51260818 cites W1987583739 @default.
- W51260818 cites W1989011756 @default.
- W51260818 cites W1991560045 @default.
- W51260818 cites W1991720510 @default.
- W51260818 cites W1996926729 @default.
- W51260818 cites W1999269806 @default.
- W51260818 cites W1999805448 @default.
- W51260818 cites W2002679195 @default.
- W51260818 cites W2005735942 @default.
- W51260818 cites W2007323926 @default.
- W51260818 cites W2008207811 @default.
- W51260818 cites W2008732408 @default.
- W51260818 cites W2008807546 @default.
- W51260818 cites W2015175027 @default.
- W51260818 cites W2017861498 @default.
- W51260818 cites W2018316252 @default.
- W51260818 cites W2020433571 @default.
- W51260818 cites W2022704908 @default.
- W51260818 cites W2025074364 @default.
- W51260818 cites W2026541961 @default.
- W51260818 cites W2027740340 @default.
- W51260818 cites W2028583641 @default.
- W51260818 cites W2034461961 @default.
- W51260818 cites W2041659572 @default.
- W51260818 cites W2043510207 @default.
- W51260818 cites W2048728930 @default.
- W51260818 cites W2049003872 @default.
- W51260818 cites W2055214702 @default.
- W51260818 cites W2060213717 @default.
- W51260818 cites W2064210252 @default.
- W51260818 cites W2065921473 @default.
- W51260818 cites W2068068897 @default.
- W51260818 cites W2069745024 @default.
- W51260818 cites W2076849957 @default.
- W51260818 cites W2078474886 @default.
- W51260818 cites W2078724155 @default.
- W51260818 cites W2080182910 @default.
- W51260818 cites W2084813596 @default.
- W51260818 cites W2084879398 @default.
- W51260818 cites W2087294184 @default.
- W51260818 cites W2087887322 @default.
- W51260818 cites W2091480785 @default.
- W51260818 cites W2091827119 @default.
- W51260818 cites W2094063999 @default.
- W51260818 cites W2095974123 @default.
- W51260818 cites W2095998476 @default.
- W51260818 cites W2097572021 @default.
- W51260818 cites W2098126158 @default.
- W51260818 cites W2099414888 @default.
- W51260818 cites W2102887078 @default.
- W51260818 cites W2108080167 @default.
- W51260818 cites W2108767532 @default.
- W51260818 cites W2108979661 @default.
- W51260818 cites W2109618665 @default.
- W51260818 cites W2111139432 @default.
- W51260818 cites W2115186758 @default.
- W51260818 cites W2115221577 @default.
- W51260818 cites W2117316548 @default.
- W51260818 cites W2118279566 @default.
- W51260818 cites W2122599809 @default.
- W51260818 cites W2124030672 @default.
- W51260818 cites W2129237258 @default.
- W51260818 cites W2133241378 @default.
- W51260818 cites W2133704193 @default.
- W51260818 cites W2139044529 @default.
- W51260818 cites W2140494588 @default.
- W51260818 cites W2140523898 @default.
- W51260818 cites W2140628140 @default.
- W51260818 cites W2145484948 @default.