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- W51276250 abstract "Oxidants play an important role in pulmonary fibrosis. We investigated the oxidative stress (OS) markers in the lungs of different mouse strains. Male C57BL/6, DBA/2 and BALB/c mice were divided in Control group (50μl saline; i.t., N = 10 each strain) and Bleomycin group [B] (0.1 U/kg i.t., N = 10 each strain). After 21 days, lung mechanics was assessed and then mice were killed; lungs were homogenized for OS markers measurement. Statistical analysis compared B groups with their respective controls. Elastance, and both peripheral and central lung resistance were only increased in C57BL/6 group (p<0.05). MDA levels were increased in the C57BL/6-B group (p<0.01), but were decreased in DBA/2 and BALB/c-B groups (p<0.0001). Both activity and expression of catalase were increased in C57BL/6-B groups (p<0.01), but were decreased in BALB/c-B groups (p<0.01). SOD activity increased in C57BL/6 and BALB/c-B groups (p<0.01). Nitrite increased in C57BL/6 and BALB/c (p<0.01) groups. Our results show C57BL/6 mice are more susceptible to redox imbalance and oxidative damage. Also, BALB/c strain show some degree of redox imbalance; however DBA and BALB/c strains seem to be resistant to oxidative damage.Financial Support: CAPES, UERJ, CNPq" @default.
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- W51276250 date "2011-04-01" @default.
- W51276250 modified "2023-09-23" @default.
- W51276250 title "Oxidative Stress is Strain Dependent in Bleomycin‐induced Pulmonary Fibrosis" @default.
- W51276250 doi "https://doi.org/10.1096/fasebj.25.1_supplement.114.8" @default.
- W51276250 hasPublicationYear "2011" @default.
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