Matches in SemOpenAlex for { <https://semopenalex.org/work/W51445793> ?p ?o ?g. }
- W51445793 endingPage "785" @default.
- W51445793 startingPage "776" @default.
- W51445793 abstract "Ocular surface mucosa is the first-line ocular tissue to be exposed to environmental stress. We evaluated tear functions and keratoconjunctival epithelial alterations after sidestream cigarette smoke (SCS) exposure and tried to clarify the role of the transcription factor nuclear factor erythroid 2-related factor 2 (Nfe2l2, also known as Nrf2), on the ocular surface. In wild-type and Nrf2(-/-) mice, tear volume did not change after SCS exposure. Tear film breakup time (tear stability) in Nrf2(-/-) mice was significantly shorter than that in wild-type mice after SCS exposure. Vital staining scores, including fluorescein and Rose Bengal staining, showed significantly higher values in Nrf2(-/-) mice than in wild-type mice after SCS exposure. Excessive oxidative stress accumulation was detected in Nrf2(-/-) mice after SCS exposure using immunohistochemical analysis. Immunohistochemical analysis also revealed decreased mucin 1 (Muc1) and Muc5ac staining in Nrf2(-/-) mice after SCS exposure. mRNA expression levels of Muc1, Muc4, and Muc5ac and of SAM-pointed domain epithelial-specific transcription factor in Nrf2(-/-) mice were lower than those in wild-type mice after SCS exposure. Mean tear IL-6 concentrations increased significantly in Nrf2(-/-) mice after SCS exposure. In conclusion, SCS exposure induced decreased tear stability, ocular surface damage, and altered conjunctival phenotype in Nrf2(-/-) mice. Nrf2 could play an important role in protection of the ocular surface against SCS exposure." @default.
- W51445793 created "2016-06-24" @default.
- W51445793 creator A5000405522 @default.
- W51445793 creator A5002160779 @default.
- W51445793 creator A5026717529 @default.
- W51445793 creator A5030770573 @default.
- W51445793 creator A5039573324 @default.
- W51445793 creator A5069583347 @default.
- W51445793 creator A5073006246 @default.
- W51445793 date "2015-03-01" @default.
- W51445793 modified "2023-10-15" @default.
- W51445793 title "The Effect of Nrf2 Knockout on Ocular Surface Protection from Acute Tobacco Smoke Exposure" @default.
- W51445793 cites W1855379264 @default.
- W51445793 cites W1974120192 @default.
- W51445793 cites W1977736016 @default.
- W51445793 cites W1977804319 @default.
- W51445793 cites W1981976464 @default.
- W51445793 cites W1982000100 @default.
- W51445793 cites W1990326740 @default.
- W51445793 cites W1991631628 @default.
- W51445793 cites W2000983790 @default.
- W51445793 cites W2003867270 @default.
- W51445793 cites W2007976366 @default.
- W51445793 cites W2012576876 @default.
- W51445793 cites W2022587708 @default.
- W51445793 cites W2026919938 @default.
- W51445793 cites W2027085316 @default.
- W51445793 cites W2030759718 @default.
- W51445793 cites W2032631038 @default.
- W51445793 cites W2036809698 @default.
- W51445793 cites W2043909055 @default.
- W51445793 cites W2048005287 @default.
- W51445793 cites W2048392510 @default.
- W51445793 cites W2053401639 @default.
- W51445793 cites W2059240823 @default.
- W51445793 cites W2062762533 @default.
- W51445793 cites W2066583147 @default.
- W51445793 cites W2072294952 @default.
- W51445793 cites W2084644507 @default.
- W51445793 cites W2097483946 @default.
- W51445793 cites W2098998588 @default.
- W51445793 cites W2101900458 @default.
- W51445793 cites W2123142399 @default.
- W51445793 cites W2124346518 @default.
- W51445793 cites W2125628149 @default.
- W51445793 cites W2129476710 @default.
- W51445793 cites W2137894554 @default.
- W51445793 cites W2138321161 @default.
- W51445793 cites W2144049496 @default.
- W51445793 cites W2146962699 @default.
- W51445793 cites W2158606960 @default.
- W51445793 cites W2160627395 @default.
- W51445793 cites W59598710 @default.
- W51445793 doi "https://doi.org/10.1016/j.ajpath.2014.11.014" @default.
- W51445793 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25701884" @default.
- W51445793 hasPublicationYear "2015" @default.
- W51445793 type Work @default.
- W51445793 sameAs 51445793 @default.
- W51445793 citedByCount "14" @default.
- W51445793 countsByYear W514457932015 @default.
- W51445793 countsByYear W514457932016 @default.
- W51445793 countsByYear W514457932017 @default.
- W51445793 countsByYear W514457932018 @default.
- W51445793 countsByYear W514457932019 @default.
- W51445793 countsByYear W514457932020 @default.
- W51445793 countsByYear W514457932021 @default.
- W51445793 countsByYear W514457932022 @default.
- W51445793 crossrefType "journal-article" @default.
- W51445793 hasAuthorship W51445793A5000405522 @default.
- W51445793 hasAuthorship W51445793A5002160779 @default.
- W51445793 hasAuthorship W51445793A5026717529 @default.
- W51445793 hasAuthorship W51445793A5030770573 @default.
- W51445793 hasAuthorship W51445793A5039573324 @default.
- W51445793 hasAuthorship W51445793A5069583347 @default.
- W51445793 hasAuthorship W51445793A5073006246 @default.
- W51445793 hasBestOaLocation W514457931 @default.
- W51445793 hasConcept C126322002 @default.
- W51445793 hasConcept C134018914 @default.
- W51445793 hasConcept C142724271 @default.
- W51445793 hasConcept C16685009 @default.
- W51445793 hasConcept C170493617 @default.
- W51445793 hasConcept C179264091 @default.
- W51445793 hasConcept C182704531 @default.
- W51445793 hasConcept C204232928 @default.
- W51445793 hasConcept C2776151105 @default.
- W51445793 hasConcept C2780898351 @default.
- W51445793 hasConcept C54355233 @default.
- W51445793 hasConcept C71924100 @default.
- W51445793 hasConcept C74864618 @default.
- W51445793 hasConcept C86803240 @default.
- W51445793 hasConceptScore W51445793C126322002 @default.
- W51445793 hasConceptScore W51445793C134018914 @default.
- W51445793 hasConceptScore W51445793C142724271 @default.
- W51445793 hasConceptScore W51445793C16685009 @default.
- W51445793 hasConceptScore W51445793C170493617 @default.
- W51445793 hasConceptScore W51445793C179264091 @default.
- W51445793 hasConceptScore W51445793C182704531 @default.
- W51445793 hasConceptScore W51445793C204232928 @default.