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- W51455045 startingPage "95.6" @default.
- W51455045 abstract "Abstract Hematological malignancies, such as leukemia and lymphoma, can develop from aberrant changes in cell signaling molecules that drive uncontrolled cell proliferation. Although there are numerous effector molecules that promote activation and expansion of T cells, one key pathway is the JAK (Janus Kinase)-STAT (Signal transducer and activator of transcription) cascade. These signaling proteins are activated in response to an array of cytokines, however constitutively activated JAKs and STATs have been described in several T cell malignancies. Indeed, a growing body of evidence suggests that dysregulated STAT5 may be a major contributor to certain types of T cell cancers. In addition to tyrosine phosphorylation of STAT5, serine phosphorylation within a Proline-Serine-Proline (PSP) or PXSP motif, located in the transactivation domain may also be equally important to its activation status, however the STAT5 serine-threonine kinase is not immediately known. Therefore, using a siRNA directed “loss of function” approach, proline directed serine/threonine kinases were screened for their ability to phosphorylate STAT5 in an IL-2 dependent manner. The results from this assay provide interesting insight into this family of kinases and their role in STAT5 regulation. Additionally, the data offers new information into the functional role of STAT5 serine phosphorylation and provides possible new therapeutic strategies for controlling diseases dependent upon this key signaling pathway." @default.
- W51455045 created "2016-06-24" @default.
- W51455045 creator A5085570553 @default.
- W51455045 date "2010-04-01" @default.
- W51455045 modified "2023-09-25" @default.
- W51455045 title "Identification and characterization of putative proline directed serine/threonine kinase(s) directed against a functional PSP motif in STAT5 (95.6)" @default.
- W51455045 doi "https://doi.org/10.4049/jimmunol.184.supp.95.6" @default.
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