FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W51523625> ?p ?o ?g. }

• W51523625 endingPage "1501" @default.
• W51523625 startingPage "1496" @default.
• W51523625 abstract "Abstract Although acute lymphoblastic leukemia (ALL) is the most common childhood cancer, factors governing susceptibility to this disease have not yet been identified. As such, ALL offers a useful opportunity to examine the glutathione S-transferase and cytochrome P450 genes in determining susceptibility to pediatric cancers. Both enzymes are involved in carcinogen metabolism and have been shown to influence the risk a variety of solid tumors in adults. To determine whether these genes played a similar role in childhood leukemogenesis, we compared the allele frequencies of 177 childhood ALL patients and 304 controls for the CYP1A1, CYP2D6, GSTM1, and GSTT1 genes. We chose the French population of Quebec as our study population because of its relative genetic homogeneity. The GSTM1 null and CYP1A1*2A genotypes were both found to be significant predictors of ALL risk (odds ratio [OR] = 1.8). Those possessing both genotypes were at an even greater risk of developing the disease (OR = 3.3). None of the other alleles tested for proved to be significant indicators of ALL risk. Unexpectedly, girls carrying the CYP1A1∗4 were significantly underrepresented in the ALL group (OR = 0.2), suggesting that a gender-specific protective role exists for this allele. These results suggest that the risk of ALL may indeed be associated with xenobiotics-metabolism, and thus with environmental exposures. Our findings may also explain, in part, why ALL is more prevalent among males than females." @default.
• W51523625 created "2016-06-24" @default.
• W51523625 creator A5010996276 @default.
• W51523625 creator A5034064114 @default.
• W51523625 creator A5035824049 @default.
• W51523625 creator A5039922554 @default.
• W51523625 creator A5068453737 @default.
• W51523625 date "1999-03-01" @default.
• W51523625 modified "2023-10-14" @default.
• W51523625 title "Susceptibility to Childhood Acute Lymphoblastic Leukemia: Influence of CYP1A1, CYP2D6, GSTM1, and GSTT1 Genetic Polymorphisms" @default.
• W51523625 cites W1480853465 @default.
• W51523625 cites W152275921 @default.
• W51523625 cites W1750764013 @default.
• W51523625 cites W1835327802 @default.
• W51523625 cites W1848867726 @default.
• W51523625 cites W1974372375 @default.
• W51523625 cites W1978674872 @default.
• W51523625 cites W1978850736 @default.
• W51523625 cites W1980626524 @default.
• W51523625 cites W1984158775 @default.
• W51523625 cites W1987791430 @default.
• W51523625 cites W1989108484 @default.
• W51523625 cites W1997220089 @default.
• W51523625 cites W1999463250 @default.
• W51523625 cites W2002240712 @default.
• W51523625 cites W2010347552 @default.
• W51523625 cites W2021552125 @default.
• W51523625 cites W2024480573 @default.
• W51523625 cites W2034006678 @default.
• W51523625 cites W2035779563 @default.
• W51523625 cites W2048062115 @default.
• W51523625 cites W2052896891 @default.
• W51523625 cites W2057546704 @default.
• W51523625 cites W2059125189 @default.
• W51523625 cites W2060033869 @default.
• W51523625 cites W2064595171 @default.
• W51523625 cites W2066322042 @default.
• W51523625 cites W2069296209 @default.
• W51523625 cites W2080597419 @default.
• W51523625 cites W2086172640 @default.
• W51523625 cites W2088304719 @default.
• W51523625 cites W2107428252 @default.
• W51523625 cites W2114381434 @default.
• W51523625 cites W2126704418 @default.
• W51523625 cites W2149455835 @default.
• W51523625 cites W2242790540 @default.
• W51523625 cites W2419440397 @default.
• W51523625 cites W4230626149 @default.
• W51523625 cites W4235751728 @default.
• W51523625 cites W4372097243 @default.
• W51523625 doi "https://doi.org/10.1182/blood.v93.5.1496" @default.
• W51523625 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10029576" @default.
• W51523625 hasPublicationYear "1999" @default.
• W51523625 type Work @default.
• W51523625 sameAs 51523625 @default.
• W51523625 citedByCount "225" @default.
• W51523625 countsByYear W515236252012 @default.
• W51523625 countsByYear W515236252013 @default.
• W51523625 countsByYear W515236252014 @default.
• W51523625 countsByYear W515236252015 @default.
• W51523625 countsByYear W515236252016 @default.
• W51523625 countsByYear W515236252017 @default.
• W51523625 countsByYear W515236252018 @default.
• W51523625 countsByYear W515236252019 @default.
• W51523625 countsByYear W515236252020 @default.
• W51523625 countsByYear W515236252021 @default.
• W51523625 countsByYear W515236252022 @default.
• W51523625 crossrefType "journal-article" @default.
• W51523625 hasAuthorship W51523625A5010996276 @default.
• W51523625 hasAuthorship W51523625A5034064114 @default.
• W51523625 hasAuthorship W51523625A5035824049 @default.
• W51523625 hasAuthorship W51523625A5039922554 @default.
• W51523625 hasAuthorship W51523625A5068453737 @default.
• W51523625 hasConcept C104317684 @default.
• W51523625 hasConcept C126322002 @default.
• W51523625 hasConcept C135763542 @default.
• W51523625 hasConcept C156957248 @default.
• W51523625 hasConcept C180754005 @default.
• W51523625 hasConcept C203014093 @default.
• W51523625 hasConcept C2778461978 @default.
• W51523625 hasConcept C2779134260 @default.
• W51523625 hasConcept C2779401946 @default.
• W51523625 hasConcept C2908647359 @default.
• W51523625 hasConcept C2909962599 @default.
• W51523625 hasConcept C33664856 @default.
• W51523625 hasConcept C54355233 @default.
• W51523625 hasConcept C67636389 @default.
• W51523625 hasConcept C71924100 @default.
• W51523625 hasConcept C86803240 @default.
• W51523625 hasConcept C99454951 @default.
• W51523625 hasConceptScore W51523625C104317684 @default.
• W51523625 hasConceptScore W51523625C126322002 @default.
• W51523625 hasConceptScore W51523625C135763542 @default.
• W51523625 hasConceptScore W51523625C156957248 @default.
• W51523625 hasConceptScore W51523625C180754005 @default.
• W51523625 hasConceptScore W51523625C203014093 @default.
• W51523625 hasConceptScore W51523625C2778461978 @default.
• W51523625 hasConceptScore W51523625C2779134260 @default.

• next